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CDC6 | cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated (560 aa) | |||
NT5C1A | 5’-nucleotidase, cytosolic IA; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia (368 aa) | |||
UBE2K | ubiquitin-conjugating enzyme E2K (200 aa) | |||
CCNE1 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition (410 aa) | |||
E2F3 | E2F transcription factor 3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner (465 aa) | |||
AMT | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) (403 aa) | |||
UNK | unkempt homolog (Drosophila) (886 aa) | |||
ENTPD3 | ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP (529 aa) | |||
DTYMK | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP (212 aa) | |||
TYMS | thymidylate synthetase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (313 aa) | |||
DHFRL1 | dihydrofolate reductase-like 1; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR (187 aa) | |||
UBC | ubiquitin C (685 aa) | |||
ZFYVE19 | zinc finger, FYVE domain containing 19 (471 aa) | |||
UBE2C | ubiquitin-conjugating enzyme E2C; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 11’- and ’Lys-48’-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating ’Lys-11’-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (179 aa) | |||
DCTD | dCMP deaminase; Supplies the nucleotide substrate for thymidylate synthetase (189 aa) | |||
RRM2 | ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (449 aa) | |||
UBQLN4 | ubiquilin 4; Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation (601 aa) | |||
ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 (522 aa) | |||
ENTPD8 | ectonucleoside triphosphate diphosphohydrolase 8; Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP (495 aa) | |||
MTHFR | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine (656 aa) | |||
WDR45L | WDR45-like (344 aa) | |||
MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (350 aa) | |||
CDK1 | cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] (297 aa) | |||
DHFR | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 (187 aa) | |||
CDC45 | cell division cycle 45 homolog (S. cerevisiae); Required for initiation of chromosomal DNA replication (598 aa) | |||
WDR1 | WD repeat domain 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity) (606 aa) |