chemokine (C-X-C motif) ligand 12

signal transducer and activator of transcription 1, 91kDa

chemokine (C-X-C motif) ligand 12

signal transducer and activator of transcription 2, 113kDa; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, wh [...]

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

interferon-induced protein 35; Not yet known

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1 [...]

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

interferon induced transmembrane protein 2; IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit- influenza virus hemagglutinin protein-mediated viral entry, MARV and EBO [...]

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

interferon regulatory factor 2; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity)

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

interferon regulatory factor 9; Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

interferon stimulated exonuclease gene 20kDa; Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

2’-5’-oligoadenylate synthetase 1, 40/46kDa

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

2’-5’-oligoadenylate synthetase 2, 69/71kDa; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2’-5’-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the [...]

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

2’-5’-oligoadenylate synthetase 3, 100kDa; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2’-5’- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in [...]

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

signal transducer and activator of transcription 2, 113kDa; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, wh [...]

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

XIAP associated factor 1

major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)

major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)

major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)

interferon-induced protein 35; Not yet known

major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)

interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1 [...]

major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)

interferon induced transmembrane protein 2; IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit- influenza virus hemagglutinin protein-mediated viral entry, MARV and EBO [...]