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STRINGSTRING
XPO6 XPO6 RAB4A RAB4A ENSG00000171570 ENSG00000171570 RANBP6 RANBP6 IPO5 IPO5 STOML1 STOML1 ATP5L2 ATP5L2 UBC UBC ELAVL1 ELAVL1 RAB4B RAB4B JAGN1 JAGN1 STOML2 STOML2 SCAMP4 SCAMP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RANBP6RAN binding protein 6; May function in nuclear protein import as nuclear transport receptor (1105 aa)
IPO5importin 5; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] (1115 aa)
XPO6exportin 6; Mediates the nuclear export of actin and profilin-actin complexes in somatic cells (1125 aa)
JAGN1jagunal homolog 1 (Drosophila); May be required for endoplasmic reticulum organization (By similarity) (183 aa)
SCAMP4secretory carrier membrane protein 4; Probably involved in membrane protein trafficking (By similarity) (229 aa)
STOML1stomatin (EPB72)-like 1 (398 aa)
UBCubiquitin C (685 aa)
STOML2stomatin (EPB72)-like 2; Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role [...] (356 aa)
RAB4BRAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (213 aa)
RAB4ARAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (218 aa)
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro (326 aa)
ATP5L2ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via [...] (100 aa)
ENSG00000171570RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (213 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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