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STRINGSTRING
KTN1 KTN1 TMPRSS4 TMPRSS4 SLN SLN CLEC7A CLEC7A KLRG1 KLRG1 CLDN7 CLDN7 MARCH2 MARCH2 SEC22A SEC22A OCLN OCLN TMEM140 TMEM140 CSGALNACT2 CSGALNACT2 TMEM248 TMEM248 PAQR5 PAQR5 SYNE4 SYNE4 TMEM182 TMEM182 CD47 CD47 TMEM115 TMEM115 ECE2 ECE2 TMEM147 TMEM147 BRICD5 BRICD5 EDDM3B EDDM3B DEFB121 DEFB121 CXCL9 CXCL9 C10orf35 C10orf35 ENTPD3 ENTPD3 TSPAN15 TSPAN15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MARCH2membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6 (246 aa)
TMEM147transmembrane protein 147 (224 aa)
TMEM115transmembrane protein 115 (351 aa)
TMEM140transmembrane protein 140 (185 aa)
ENTPD3ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP (529 aa)
CLEC7AC-type lectin domain family 7, member A (247 aa)
SLNsarcolipin (31 aa)
SEC22ASEC22 vesicle trafficking protein homolog A (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (By similarity) (307 aa)
EDDM3Bepididymal protein 3B; Possible function in sperm maturation (147 aa)
SYNE4spectrin repeat containing, nuclear envelope family member 4; Contributes to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity) (404 aa)
BRICD5BRICHOS domain containing 5 (228 aa)
TMEM248transmembrane protein 248 (314 aa)
PAQR5progestin and adipoQ receptor family member V; Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (330 aa)
OCLNoccludin (522 aa)
KLRG1killer cell lectin-like receptor subfamily G, member 1; Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells (189 aa)
CLDN7claudin 7; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) (211 aa)
CXCL9chemokine (C-X-C motif) ligand 9; Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3 (125 aa)
CD47CD47 molecule; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integr [...] (323 aa)
C10orf35chromosome 10 open reading frame 35 (121 aa)
TSPAN15tetraspanin 15 (294 aa)
CSGALNACT2chondroitin sulfate N-acetylgalactosaminyltransferase 2; Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains (542 aa)
KTN1kinectin 1 (kinesin receptor); Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin (1357 aa)
ECE2endothelin converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity (883 aa)
TMEM182transmembrane protein 182 (229 aa)
TMPRSS4transmembrane protease, serine 4; Probable protease. Seems to be capable of activating ENaC (By similarity) (437 aa)
DEFB121defensin, beta 121; Has antibacterial activity (Potential) (76 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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