node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CXCL9 | SFTPC | ENSP00000354901 | ENSP00000316152 | chemokine (C-X-C motif) ligand 9; Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3 | surfactant protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces | 0.618 |
DNAJB9 | DNAJC10 | ENSP00000249356 | ENSP00000264065 | DnaJ (Hsp40) homolog, subfamily B, member 9; Acts as a co-chaperone with an Hsp70 protein (By similarity) | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.455 |
DNAJB9 | HSPA5 | ENSP00000249356 | ENSP00000324173 | DnaJ (Hsp40) homolog, subfamily B, member 9; Acts as a co-chaperone with an Hsp70 protein (By similarity) | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.979 |
DNAJB9 | SFTPC | ENSP00000249356 | ENSP00000316152 | DnaJ (Hsp40) homolog, subfamily B, member 9; Acts as a co-chaperone with an Hsp70 protein (By similarity) | surfactant protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces | 0.705 |
DNAJB9 | VCP | ENSP00000249356 | ENSP00000351777 | DnaJ (Hsp40) homolog, subfamily B, member 9; Acts as a co-chaperone with an Hsp70 protein (By similarity) | valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...] | 0.647 |
DNAJC10 | DNAJB9 | ENSP00000264065 | ENSP00000249356 | DnaJ (Hsp40) homolog, subfamily C, member 10 | DnaJ (Hsp40) homolog, subfamily B, member 9; Acts as a co-chaperone with an Hsp70 protein (By similarity) | 0.455 |
DNAJC10 | HSPA5 | ENSP00000264065 | ENSP00000324173 | DnaJ (Hsp40) homolog, subfamily C, member 10 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.999 |
DNAJC10 | SFTPC | ENSP00000264065 | ENSP00000316152 | DnaJ (Hsp40) homolog, subfamily C, member 10 | surfactant protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces | 0.721 |
DNAJC10 | VCP | ENSP00000264065 | ENSP00000351777 | DnaJ (Hsp40) homolog, subfamily C, member 10 | valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...] | 0.941 |
HSPA5 | DNAJB9 | ENSP00000324173 | ENSP00000249356 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | DnaJ (Hsp40) homolog, subfamily B, member 9; Acts as a co-chaperone with an Hsp70 protein (By similarity) | 0.979 |
HSPA5 | DNAJC10 | ENSP00000324173 | ENSP00000264065 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.999 |
HSPA5 | SFTPC | ENSP00000324173 | ENSP00000316152 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | surfactant protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces | 0.622 |
HSPA5 | TMEM67 | ENSP00000324173 | ENSP00000389998 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | transmembrane protein 67; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC) | 0.576 |
HSPA5 | VCP | ENSP00000324173 | ENSP00000351777 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...] | 0.798 |
NEDD4 | SFTPC | ENSP00000345530 | ENSP00000316152 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | surfactant protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces | 0.617 |
SEC22A | SFTPC | ENSP00000310521 | ENSP00000316152 | SEC22 vesicle trafficking protein homolog A (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (By similarity) | surfactant protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces | 0.656 |
SEC61G | SFTPC | ENSP00000341538 | ENSP00000316152 | Sec61 gamma subunit; Necessary for protein translocation in the endoplasmic reticulum (By similarity) | surfactant protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces | 0.608 |
SFTPC | CXCL9 | ENSP00000316152 | ENSP00000354901 | surfactant protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces | chemokine (C-X-C motif) ligand 9; Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3 | 0.618 |
SFTPC | DNAJB9 | ENSP00000316152 | ENSP00000249356 | surfactant protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces | DnaJ (Hsp40) homolog, subfamily B, member 9; Acts as a co-chaperone with an Hsp70 protein (By similarity) | 0.705 |
SFTPC | DNAJC10 | ENSP00000316152 | ENSP00000264065 | surfactant protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.721 |