node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGTR1 | DNAJC14 | ENSP00000273430 | ENSP00000316240 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | 0.585 |
DDX3X | DNAJC14 | ENSP00000382840 | ENSP00000316240 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded DNA with a preference for 5’- single stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can [...] | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | 0.615 |
DDX3X | ELAVL1 | ENSP00000382840 | ENSP00000385269 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded DNA with a preference for 5’- single stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can [...] | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | 0.728 |
DNAJC14 | AGTR1 | ENSP00000316240 | ENSP00000273430 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.585 |
DNAJC14 | DDX3X | ENSP00000316240 | ENSP00000382840 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded DNA with a preference for 5’- single stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can [...] | 0.615 |
DNAJC14 | DRD1 | ENSP00000316240 | ENSP00000327652 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | dopamine receptor D1; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase | 0.937 |
DNAJC14 | LYST | ENSP00000316240 | ENSP00000374443 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | lysosomal trafficking regulator; May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules | 0.487 |
DRD1 | DNAJC14 | ENSP00000327652 | ENSP00000316240 | dopamine receptor D1; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | 0.937 |
ELAVL1 | DDX3X | ENSP00000385269 | ENSP00000382840 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded DNA with a preference for 5’- single stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can [...] | 0.728 |
LYST | DNAJC14 | ENSP00000374443 | ENSP00000316240 | lysosomal trafficking regulator; May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | 0.487 |