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TMEM14B TMEM14B ATP6V1E1 ATP6V1E1 TXN TXN TMEM126A TMEM126A TMEM14C TMEM14C EWSR1 EWSR1 C15orf48 C15orf48 SSR1 SSR1 SFXN1 SFXN1 PRKCDBP PRKCDBP UBQLN1 UBQLN1 RCN2 RCN2 APOOL APOOL MTHFD1 MTHFD1 SFXN3 SFXN3 TOMM70A TOMM70A PTPMT1 PTPMT1 TOMM7 TOMM7 TIMM50 TIMM50 ACAT1 ACAT1 TAP1 TAP1 UQCRFS1 UQCRFS1 COQ9 COQ9 LY6E LY6E UQCRQ UQCRQ ATP5L ATP5L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SFXN3sideroflexin 3; Potential iron transporter (325 aa)
TMEM14Ctransmembrane protein 14C; Required for normal heme biosynthesis (By similarity) (112 aa)
SSR1signal sequence receptor, alpha (286 aa)
ATP6V1E1ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (226 aa)
COQ9coenzyme Q9 homolog (S. cerevisiae); Involved in the biosynthesis of coenzyme Q (By similarity) (318 aa)
ACAT1acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism (427 aa)
TOMM70Atranslocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae); Receptor that accelerates the import of all mitochondrial precursor proteins (By similarity) (608 aa)
LY6Elymphocyte antigen 6 complex, locus E (131 aa)
ATP5LATP synthase, H+ transporting, mitochondrial Fo complex, subunit G; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a [...] (103 aa)
UQCRFS1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (274 aa)
TMEM126Atransmembrane protein 126A (195 aa)
PRKCDBPprotein kinase C, delta binding protein; Seems to have an immune potentiation function (By similarity) (261 aa)
SFXN1sideroflexin 1; Might be involved in the transport of a component required for iron utilization into or out of the mitochondria (322 aa)
TIMM50translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body (456 aa)
PTPMT1protein tyrosine phosphatase, mitochondrial 1; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylat [...] (201 aa)
C15orf48chromosome 15 open reading frame 48 (83 aa)
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) (808 aa)
TOMM7translocase of outer mitochondrial membrane 7 homolog (yeast); Required for assembly and stability of the TOM complex (55 aa)
APOOLapolipoprotein O-like (268 aa)
TXNthioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates A [...] (105 aa)
UBQLN1ubiquilin 1; Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation (589 aa)
UQCRQubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone (82 aa)
TMEM14Btransmembrane protein 14B (114 aa)
RCN2reticulocalbin 2, EF-hand calcium binding domain; Not known. Binds calcium (317 aa)
EWSR1Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes (661 aa)
MTHFD1methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (935 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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