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SLC38A11 SLC38A11 MIP MIP SLC38A9 SLC38A9 MOSPD3 MOSPD3 AQP5 AQP5 SLC36A4 SLC36A4 SLC38A8 SLC38A8 SLC38A10 SLC38A10 CCNG1 CCNG1 PPP2CA PPP2CA SLC38A7 SLC38A7 RAB12 RAB12 AQP4 AQP4 LAMP2 LAMP2 SLC38A1 SLC38A1 CBFA2T2 CBFA2T2 SLC32A1 SLC32A1 AQP2 AQP2 FBXL17 FBXL17 AQP8 AQP8 AQP1 AQP1 SLC38A6 SLC38A6 AQP6 AQP6 USP26 USP26 UBQLN1 UBQLN1 ENSG00000250424 ENSG00000250424
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
AQP2aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (271 aa)
SLC32A1solute carrier family 32 (GABA vesicular transporter), member 1; Involved in the uptake of GABA and glycine into the synaptic vesicles (525 aa)
SLC38A7solute carrier family 38, member 7; Mediates sodium-dependent transport of amino acids, preferentially L-glutamine (By similarity) (462 aa)
AQP8aquaporin 8; Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea (261 aa)
MOSPD3motile sperm domain containing 3 (235 aa)
MIPmajor intrinsic protein of lens fiber; Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity) (263 aa)
CBFA2T2core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (604 aa)
AQP5aquaporin 5; Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions (265 aa)
SLC38A8solute carrier family 38, member 8; Putative sodium-dependent amino acid/proton antiporter (By similarity) (435 aa)
AQP1aquaporin 1 (Colton blood group); Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (269 aa)
SLC38A9solute carrier family 38, member 9; Putative sodium-dependent amino acid/proton antiporter (By similarity) (561 aa)
SLC36A4solute carrier family 36 (proton/amino acid symporter), member 4; Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine (504 aa)
AQP6aquaporin 6, kidney specific; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism (By similarity) (282 aa)
RAB12RAB12, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor (By similarity) (244 aa)
CCNG1cyclin G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity) (295 aa)
SLC38A6solute carrier family 38, member 6; Probable sodium-dependent amino acid/proton antiporter (521 aa)
USP26ubiquitin specific peptidase 26; Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway (913 aa)
SLC38A10solute carrier family 38, member 10; Putative sodium-dependent amino acid/proton antiporter (By similarity) (1119 aa)
UBQLN1ubiquilin 1; Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation (589 aa)
AQP4aquaporin 4; Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system (323 aa)
SLC38A1solute carrier family 38, member 1; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1-1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA (487 aa)
SLC38A11solute carrier family 38, member 11; Putative sodium-dependent amino acid/proton antiporter (By similarity) (406 aa)
LAMP2lysosomal-associated membrane protein 2; Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens (411 aa)
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ’Ser-259’ (309 aa)
ENSG00000250424Uncharacterized protein (446 aa)
FBXL17F-box and leucine-rich repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) (701 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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