node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C14orf93 | MRFAP1 | ENSP00000299088 | ENSP00000318352 | chromosome 14 open reading frame 93 | Morf4 family associated protein 1 | 0.557 |
CACNA1B | MRFAP1 | ENSP00000360406 | ENSP00000318352 | calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). [...] | Morf4 family associated protein 1 | 0.418 |
DCDC2 | MRFAP1 | ENSP00000367715 | ENSP00000318352 | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | Morf4 family associated protein 1 | 0.590 |
MORF4L1 | MORF4L2 | ENSP00000331310 | ENSP00000353643 | mortality factor 4 like 1 | mortality factor 4 like 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senesce [...] | 0.956 |
MORF4L1 | MRFAP1 | ENSP00000331310 | ENSP00000318352 | mortality factor 4 like 1 | Morf4 family associated protein 1 | 0.997 |
MORF4L1 | MRFAP1L1 | ENSP00000331310 | ENSP00000318154 | mortality factor 4 like 1 | Morf4 family associated protein 1-like 1 | 0.875 |
MORF4L1 | MRGBP | ENSP00000331310 | ENSP00000359518 | mortality factor 4 like 1 | MRG/MORF4L binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | 0.999 |
MORF4L1 | RB1 | ENSP00000331310 | ENSP00000267163 | mortality factor 4 like 1 | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.814 |
MORF4L1 | TRRAP | ENSP00000331310 | ENSP00000347733 | mortality factor 4 like 1 | transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription acti [...] | 0.984 |
MORF4L2 | MORF4L1 | ENSP00000353643 | ENSP00000331310 | mortality factor 4 like 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senesce [...] | mortality factor 4 like 1 | 0.956 |
MORF4L2 | MRFAP1 | ENSP00000353643 | ENSP00000318352 | mortality factor 4 like 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senesce [...] | Morf4 family associated protein 1 | 0.937 |
MORF4L2 | MRGBP | ENSP00000353643 | ENSP00000359518 | mortality factor 4 like 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senesce [...] | MRG/MORF4L binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | 0.999 |
MORF4L2 | RB1 | ENSP00000353643 | ENSP00000267163 | mortality factor 4 like 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senesce [...] | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.567 |
MORF4L2 | TRRAP | ENSP00000353643 | ENSP00000347733 | mortality factor 4 like 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senesce [...] | transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription acti [...] | 0.896 |
MRFAP1 | C14orf93 | ENSP00000318352 | ENSP00000299088 | Morf4 family associated protein 1 | chromosome 14 open reading frame 93 | 0.557 |
MRFAP1 | CACNA1B | ENSP00000318352 | ENSP00000360406 | Morf4 family associated protein 1 | calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). [...] | 0.418 |
MRFAP1 | DCDC2 | ENSP00000318352 | ENSP00000367715 | Morf4 family associated protein 1 | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | 0.590 |
MRFAP1 | MORF4L1 | ENSP00000318352 | ENSP00000331310 | Morf4 family associated protein 1 | mortality factor 4 like 1 | 0.997 |
MRFAP1 | MORF4L2 | ENSP00000318352 | ENSP00000353643 | Morf4 family associated protein 1 | mortality factor 4 like 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senesce [...] | 0.937 |
MRFAP1 | MRGBP | ENSP00000318352 | ENSP00000359518 | Morf4 family associated protein 1 | MRG/MORF4L binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | 0.527 |