Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | XPO7 | exportin 7; Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate ano [...] (1087 aa) | ||
 | COG3 | component of oligomeric golgi complex 3; Involved in ER-Golgi transport (828 aa) | ||
 | RAB21 | RAB21, member RAS oncogene family; Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (225 aa) | ||
 | CSE1L | CSE1 chromosome segregation 1-like (yeast) (971 aa) | ||
 | XPO5 | exportin 5 (1204 aa) | ||
 | TAPBPL | TAP binding protein-like (468 aa) | ||
 | DYM | dymeclin (669 aa) | ||
 | CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1; Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells (461 aa) | ||
 | COG5 | component of oligomeric golgi complex 5; Required for normal Golgi function (By similarity) (860 aa) | ||
 | XPO6 | exportin 6; Mediates the nuclear export of actin and profilin-actin complexes in somatic cells (1125 aa) | ||
 | COG7 | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) (770 aa) | ||
 | COG8 | component of oligomeric golgi complex 8; Required for normal Golgi function (By similarity) (612 aa) | ||
 | COG4 | component of oligomeric golgi complex 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (789 aa) | ||
 | VSIG2 | V-set and immunoglobulin domain containing 2 (327 aa) | ||
 | IGSF3 | immunoglobulin superfamily, member 3 (1214 aa) | ||
 | TNPO1 | transportin 1; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis [...] (898 aa) | ||
 | COG2 | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function (738 aa) | ||
 | HLA-A | major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity) (365 aa) | ||
 | COG6 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) (657 aa) | ||
 | HLA-B | major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity) (362 aa) | ||
 | ENSG00000240215 | T cell receptor beta variable 25/OR9-2 (pseudogene) (112 aa) | ||
 | IGLL5 | immunoglobulin lambda-like polypeptide 5 (214 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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