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TGFBI TGFBI RAD51B RAD51B BLOC1S2 BLOC1S2 CENPL CENPL YARS2 YARS2 PHYH PHYH TRMT61B TRMT61B EBNA1BP2 EBNA1BP2 NDE1 NDE1 DENND2D DENND2D ACP6 ACP6 SERPINE2 SERPINE2 NDUFB10 NDUFB10 FAM9B FAM9B MRPL9 MRPL9 ANKRD36C ANKRD36C CMTM6 CMTM6 C16orf72 C16orf72 GPX1 GPX1 DAPK2 DAPK2 AURKAIP1 AURKAIP1 CDC42EP4 CDC42EP4 RMND1 RMND1 DNAJC4 DNAJC4 PTRH1 PTRH1 LYRM2 LYRM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CMTM6CKLF-like MARVEL transmembrane domain containing 6 (183 aa)
DAPK2death-associated protein kinase 2; Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in g [...] (370 aa)
PHYHphytanoyl-CoA 2-hydroxylase; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA (338 aa)
NDUFB10NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (172 aa)
TRMT61BtRNA methyltransferase 61 homolog B (S. cerevisiae); Methyltransferase that catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (decephering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (decephering codons UCA, UCU, UCG or UCC) (477 aa)
FAM9Bfamily with sequence similarity 9, member B (186 aa)
AURKAIP1aurora kinase A interacting protein 1; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation (199 aa)
YARS2tyrosyl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) (477 aa)
C16orf72chromosome 16 open reading frame 72 (275 aa)
CDC42EP4CDC42 effector protein (Rho GTPase binding) 4; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts (356 aa)
NDE1nudE nuclear distribution E homolog 1 (A. nidulans); Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative [...] (335 aa)
CENPLcentromere protein L; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (390 aa)
DENND2DDENN/MADD domain containing 2D; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form (471 aa)
RMND1required for meiotic nuclear division 1 homolog (S. cerevisiae); Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome (449 aa)
MRPL9mitochondrial ribosomal protein L9 (267 aa)
ACP6acid phosphatase 6, lysophosphatidic; Hydrolyzes lysophosphatidic acid to monoacylglycerol (428 aa)
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 2; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May play a role in [...] (142 aa)
DNAJC4DnaJ (Hsp40) homolog, subfamily C, member 4 (241 aa)
ANKRD36Cankyrin repeat domain 36C (1778 aa)
EBNA1BP2EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) (361 aa)
GPX1glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown (203 aa)
SERPINE2serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin (409 aa)
TGFBItransforming growth factor, beta-induced, 68kDa (683 aa)
PTRH1peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) (214 aa)
RAD51BRAD51 homolog B (S. cerevisiae) (384 aa)
LYRM2LYR motif containing 2 (88 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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