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THAP1 | THAP domain containing, apoptosis associated protein 1; DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5’-[AT]NTNN[GT]GGCA[AGT]-3’ core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (213 aa) | |||
FAM133A | family with sequence similarity 133, member A (248 aa) | |||
STAC3 | SH3 and cysteine rich domain 3 (364 aa) | |||
SDCBP2 | syndecan binding protein (syntenin) 2 (292 aa) | |||
NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity) (506 aa) | |||
PRR13 | proline rich 13; Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane- induced apoptosis (148 aa) |