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METTL1 METTL1 EIF6 EIF6 PES1 PES1 NSUN3 NSUN3 NIP7 NIP7 NOC2L NOC2L NOC3L NOC3L TRMT11 TRMT11 CEBPZ CEBPZ RPF2 RPF2 MKI67IP MKI67IP GTPBP4 GTPBP4 RSL1D1 RSL1D1 DDX24 DDX24 WDR12 WDR12 DDX54 DDX54 MRPL15 MRPL15 RBM28 RBM28 KIAA0020 KIAA0020 WDR74 WDR74 BRIX1 BRIX1 UBC UBC DDX56 DDX56 PDCD11 PDCD11 MTHFD1 MTHFD1 MTHFD1L MTHFD1L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RBM28RNA binding motif protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes (759 aa)
CEBPZCCAAT/enhancer binding protein (C/EBP), zeta; Stimulates transcription from the HSP70 promoter (1054 aa)
NIP7nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly (180 aa)
DDX56DEAD (Asp-Glu-Ala-Asp) box helicase 56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (547 aa)
MRPL15mitochondrial ribosomal protein L15 (296 aa)
WDR12WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (423 aa)
WDR74WD repeat domain 74 (385 aa)
MKI67IPMKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa)
METTL1methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (276 aa)
NOC2Lnucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter (749 aa)
NSUN3NOP2/Sun domain family, member 3; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) (340 aa)
DDX54DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors (882 aa)
DDX24DEAD (Asp-Glu-Ala-Asp) box polypeptide 24; ATP-dependent RNA helicase (Potential) (859 aa)
TRMT11tRNA methyltransferase 11 homolog (S. cerevisiae); Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity) (463 aa)
BRIX1BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit (353 aa)
UBCubiquitin C (685 aa)
PES1pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (588 aa)
GTPBP4GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) (634 aa)
MTHFD1Lmethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity) (978 aa)
PDCD11programmed cell death 11; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (1871 aa)
NOC3Lnucleolar complex associated 3 homolog (S. cerevisiae); May be required for adipogenesis (By similarity) (800 aa)
EIF6eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity (245 aa)
KIAA0020KIAA0020 (648 aa)
RPF2ribosome production factor 2 homolog (S. cerevisiae) (306 aa)
MTHFD1methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (935 aa)
RSL1D1ribosomal L1 domain containing 1 (490 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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