node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHBP1 | MYH14 | ENSP00000263991 | ENSP00000262269 | EH domain binding protein 1 | myosin, heavy chain 14, non-muscle | 0.459 |
FZD3 | GIPC3 | ENSP00000240093 | ENSP00000319254 | frizzled family receptor 3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both p [...] | GIPC PDZ domain containing family, member 3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion (By similarity) | 0.878 |
GIPC3 | FZD3 | ENSP00000319254 | ENSP00000240093 | GIPC PDZ domain containing family, member 3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion (By similarity) | frizzled family receptor 3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both p [...] | 0.878 |
GIPC3 | MYO1F | ENSP00000319254 | ENSP00000344871 | GIPC PDZ domain containing family, member 3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion (By similarity) | myosin IF; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | 0.750 |
GIPC3 | PLEKHG5 | ENSP00000319254 | ENSP00000366977 | GIPC PDZ domain containing family, member 3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion (By similarity) | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | 0.404 |
MYH14 | EHBP1 | ENSP00000262269 | ENSP00000263991 | myosin, heavy chain 14, non-muscle | EH domain binding protein 1 | 0.459 |
MYH14 | MYO15A | ENSP00000262269 | ENSP00000205890 | myosin, heavy chain 14, non-muscle | myosin XVA; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity) | 0.454 |
MYH14 | MYO3A | ENSP00000262269 | ENSP00000265944 | myosin, heavy chain 14, non-muscle | myosin IIIA; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing | 0.456 |
MYH14 | MYO7A | ENSP00000262269 | ENSP00000386331 | myosin, heavy chain 14, non-muscle | myosin VIIA; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphoge [...] | 0.455 |
MYO15A | MYH14 | ENSP00000205890 | ENSP00000262269 | myosin XVA; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity) | myosin, heavy chain 14, non-muscle | 0.454 |
MYO15A | TMPRSS3 | ENSP00000205890 | ENSP00000291532 | myosin XVA; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity) | transmembrane protease, serine 3; Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro) | 0.517 |
MYO1F | GIPC3 | ENSP00000344871 | ENSP00000319254 | myosin IF; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | GIPC PDZ domain containing family, member 3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion (By similarity) | 0.750 |
MYO1F | MYO3A | ENSP00000344871 | ENSP00000265944 | myosin IF; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | myosin IIIA; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing | 0.448 |
MYO1F | MYO6 | ENSP00000344871 | ENSP00000358994 | myosin IF; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | myosin VI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in [...] | 0.908 |
MYO1F | MYO7A | ENSP00000344871 | ENSP00000386331 | myosin IF; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | myosin VIIA; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphoge [...] | 0.409 |
MYO3A | MYH14 | ENSP00000265944 | ENSP00000262269 | myosin IIIA; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing | myosin, heavy chain 14, non-muscle | 0.456 |
MYO3A | MYO1F | ENSP00000265944 | ENSP00000344871 | myosin IIIA; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing | myosin IF; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | 0.448 |
MYO3A | MYO6 | ENSP00000265944 | ENSP00000358994 | myosin IIIA; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing | myosin VI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in [...] | 0.933 |
MYO3A | TMPRSS3 | ENSP00000265944 | ENSP00000291532 | myosin IIIA; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing | transmembrane protease, serine 3; Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro) | 0.407 |
MYO6 | MYO1F | ENSP00000358994 | ENSP00000344871 | myosin VI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in [...] | myosin IF; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | 0.908 |