21 items (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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	MRI1	methylthioribose-1-phosphate isomerase homolog (S. cerevisiae); Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover (369 aa)
	NMI	N-myc (and STAT) interactor; May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5 (307 aa)
	ACLY	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
	DMGDH	dimethylglycine dehydrogenase (866 aa)
	AMT	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) (403 aa)
	PDPR	pyruvate dehydrogenase phosphatase regulatory subunit; Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine (By similarity) (879 aa)
	AGXT	alanine-glyoxylate aminotransferase (392 aa)
	LIPT2	lipoyl(octanoyl) transferase 2 (putative); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) (231 aa)
	SHMT1	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity) (483 aa)
	GCSH	glycine cleavage system protein H (aminomethyl carrier); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (173 aa)
	ING5	inhibitor of growth family, member 5; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (240 aa)
	SHMT2	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA (504 aa)
	LIPT1	lipoyltransferase 1; Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes (By similarity) (373 aa)
	SARDH	sarcosine dehydrogenase (918 aa)
	PSMB2	proteasome (prosome, macropain) subunit, beta type, 2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit has a trypsin-like activity (201 aa)
	FAM206A	family with sequence similarity 206, member A (181 aa)
	ECI2	enoyl-CoA delta isomerase 2 (394 aa)
	GLDC	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (1020 aa)
	SFI1	Sfi1 homolog, spindle assembly associated (yeast) (1242 aa)
	DBI	diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) (148 aa)
	RNF112	ring finger protein 112 (631 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	AGXT	ENSP00000253792	ENSP00000302620	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	alanine-glyoxylate aminotransferase	0.583
ACLY	AMT	ENSP00000253792	ENSP00000273588	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	0.554
ACLY	DMGDH	ENSP00000253792	ENSP00000255189	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	dimethylglycine dehydrogenase	0.688
ACLY	ECI2	ENSP00000253792	ENSP00000369461	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	enoyl-CoA delta isomerase 2	0.632
ACLY	GLDC	ENSP00000253792	ENSP00000370737	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.633
ACLY	PDPR	ENSP00000253792	ENSP00000288050	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	pyruvate dehydrogenase phosphatase regulatory subunit; Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine (By similarity)	0.549
ACLY	PSMB2	ENSP00000253792	ENSP00000362334	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	proteasome (prosome, macropain) subunit, beta type, 2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit has a trypsin-like activity	0.417
ACLY	SARDH	ENSP00000253792	ENSP00000360938	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	sarcosine dehydrogenase	0.567
ACLY	SHMT1	ENSP00000253792	ENSP00000318868	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.692
ACLY	SHMT2	ENSP00000253792	ENSP00000333667	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.669
AGXT	ACLY	ENSP00000302620	ENSP00000253792	alanine-glyoxylate aminotransferase	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	0.583
AGXT	DMGDH	ENSP00000302620	ENSP00000255189	alanine-glyoxylate aminotransferase	dimethylglycine dehydrogenase	0.415
AGXT	GCSH	ENSP00000302620	ENSP00000319531	alanine-glyoxylate aminotransferase	glycine cleavage system protein H (aminomethyl carrier); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	0.913
AGXT	GLDC	ENSP00000302620	ENSP00000370737	alanine-glyoxylate aminotransferase	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.965
AGXT	SARDH	ENSP00000302620	ENSP00000360938	alanine-glyoxylate aminotransferase	sarcosine dehydrogenase	0.929
AGXT	SHMT1	ENSP00000302620	ENSP00000318868	alanine-glyoxylate aminotransferase	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.963
AGXT	SHMT2	ENSP00000302620	ENSP00000333667	alanine-glyoxylate aminotransferase	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.961
AMT	ACLY	ENSP00000273588	ENSP00000253792	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	0.554
AMT	GCSH	ENSP00000273588	ENSP00000319531	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	glycine cleavage system protein H (aminomethyl carrier); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	0.999
AMT	GLDC	ENSP00000273588	ENSP00000370737	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.999

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