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SLC35D2 SLC35D2 OGN OGN GALNT14 GALNT14 LUM LUM KERA KERA GALNT10 GALNT10 MUC7 MUC7 C1GALT1C1 C1GALT1C1 B3GNT1 B3GNT1 MUCL1 MUCL1 B3GNT2 B3GNT2 GALNT1 GALNT1 GALNT5 GALNT5 B3GNT4 B3GNT4 MUC13 MUC13 GALNT8 GALNT8 B4GALT3 B4GALT3 FUT5 FUT5 GALNT7 GALNT7 MUC17 MUC17 FUT3 FUT3 GALNT11 GALNT11 FUT6 FUT6 FUT1 FUT1 FUT9 FUT9 B4GALT2 B4GALT2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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white nodes:
second shell of interactors
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Predicted Interactions
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GALNT8UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8); Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor (By similarity) (637 aa)
FUT5fucosyltransferase 5 (alpha (1,3) fucosyltransferase); May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens (374 aa)
SLC35D2solute carrier family 35, member D2; Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling (337 aa)
GALNT5UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5); Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity) (940 aa)
OGNosteoglycin; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 (298 aa)
GALNT7UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7); Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is howeve [...] (657 aa)
LUMlumican (338 aa)
KERAkeratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix (352 aa)
GALNT1UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1); Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7 (559 aa)
FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase); Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates (359 aa)
GALNT14UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) (552 aa)
GALNT10UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) (603 aa)
MUC7mucin 7, secreted; May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili (377 aa)
FUT9fucosyltransferase 9 (alpha (1,3) fucosyltransferase); Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides (359 aa)
MUC17mucin 17, cell surface associated; Probably plays a role in maintaining homeostasis on mucosal surfaces (4493 aa)
C1GALT1C1C1GALT1-specific chaperone 1; Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (318 aa)
B3GNT2UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 2; Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains (397 aa)
FUT3fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links (361 aa)
B3GNT1UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans (415 aa)
B4GALT2UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (401 aa)
MUCL1mucin-like 1; May play a role as marker for the diagnosis of metastatic breast cancer (90 aa)
FUT1fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group); Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values (365 aa)
MUC13mucin 13, cell surface associated; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling (511 aa)
GALNT11UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11); Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward Muc1, Muc4.1, and EA2 than GALNT1. Does not appear to be involved in glycosylation of erythropoietin (608 aa)
B3GNT4UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 4; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides (378 aa)
B4GALT3UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids (393 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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