node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADRB2 | AGTRAP | ENSP00000305372 | ENSP00000319713 | adrenoceptor beta 2, surface | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | 0.408 |
ADRB2 | MC1R | ENSP00000305372 | ENSP00000451605 | adrenoceptor beta 2, surface | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | 0.906 |
AGTR1 | AGTRAP | ENSP00000273430 | ENSP00000319713 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | 0.806 |
AGTR1 | EDNRB | ENSP00000273430 | ENSP00000366416 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | endothelin receptor type B | 0.913 |
AGTR1 | GNB2L1 | ENSP00000273430 | ENSP00000426909 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | 0.657 |
AGTRAP | ADRB2 | ENSP00000319713 | ENSP00000305372 | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | adrenoceptor beta 2, surface | 0.408 |
AGTRAP | AGTR1 | ENSP00000319713 | ENSP00000273430 | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.806 |
AGTRAP | CPLX1 | ENSP00000319713 | ENSP00000305613 | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | complexin 1; Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity) | 0.692 |
AGTRAP | EDNRB | ENSP00000319713 | ENSP00000366416 | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | endothelin receptor type B | 0.440 |
AGTRAP | GNB2L1 | ENSP00000319713 | ENSP00000426909 | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | 0.955 |
AGTRAP | PBX3 | ENSP00000319713 | ENSP00000362588 | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | pre-B-cell leukemia homeobox 3; Transcriptional activator that binds the sequence 5’- ATCAATCAA-3’ | 0.689 |
AGTRAP | PITPNC1 | ENSP00000319713 | ENSP00000335618 | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | phosphatidylinositol transfer protein, cytoplasmic 1; Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. Able to transfer phosphatidylinositol in vitro | 0.722 |
CPLX1 | AGTRAP | ENSP00000305613 | ENSP00000319713 | complexin 1; Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity) | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | 0.692 |
EDNRB | AGTR1 | ENSP00000366416 | ENSP00000273430 | endothelin receptor type B | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.913 |
EDNRB | AGTRAP | ENSP00000366416 | ENSP00000319713 | endothelin receptor type B | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | 0.440 |
EDNRB | GDNF | ENSP00000366416 | ENSP00000409007 | endothelin receptor type B | glial cell derived neurotrophic factor | 0.720 |
EDNRB | MC1R | ENSP00000366416 | ENSP00000451605 | endothelin receptor type B | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | 0.706 |
GDNF | EDNRB | ENSP00000409007 | ENSP00000366416 | glial cell derived neurotrophic factor | endothelin receptor type B | 0.720 |
GNB2L1 | AGTR1 | ENSP00000426909 | ENSP00000273430 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.657 |
GNB2L1 | AGTRAP | ENSP00000426909 | ENSP00000319713 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | 0.955 |