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RAB44 RAB44 RAB40A RAB40A RAB40AL RAB40AL TMF1 TMF1 RAB8B RAB8B BET3L BET3L RABIF RABIF RAB40B RAB40B TRAPPC1 TRAPPC1 RAB43 RAB43 RAB10 RAB10 TRAPPC3 TRAPPC3 RGP1 RGP1 COG2 COG2 COG7 COG7 USP6NL USP6NL COG1 COG1 COG5 COG5 VPS53 VPS53 VPS54 VPS54 VPS51 VPS51 TGOLN2 TGOLN2 GCC2 GCC2 GOLGA1 GOLGA1 GCC1 GCC1 GOLGA4 GOLGA4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RAB40ALRAB40A, member RAS oncogene family-like; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (278 aa)
RAB44RAB44, member RAS oncogene family (154 aa)
RAB10RAB10, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transpo [...] (200 aa)
VPS54vacuolar protein sorting 54 homolog (S. cerevisiae); May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (977 aa)
USP6NLUSP6 N-terminal like; Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex (845 aa)
VPS51vacuolar protein sorting 51 homolog (S. cerevisiae); Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (782 aa)
COG5component of oligomeric golgi complex 5; Required for normal Golgi function (By similarity) (860 aa)
COG1component of oligomeric golgi complex 1; Required for normal Golgi function (By similarity) (980 aa)
TRAPPC1trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi (145 aa)
COG7component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) (770 aa)
RAB40ARAB40A, member RAS oncogene family; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (277 aa)
GCC2GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (1684 aa)
RAB8BRAB8B, member RAS oncogene family; May be involved in vesicular trafficking and neurotransmitter release (By similarity). May participate in cell junction dynamics in Sertoli cells (By similarity) (207 aa)
GCC1GRIP and coiled-coil domain containing 1; Probably involved in maintaining Golgi structure (775 aa)
RAB43RAB43, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport o [...] (212 aa)
GOLGA4golgin A4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1 (2243 aa)
COG2component of oligomeric golgi complex 2; Required for normal Golgi morphology and function (738 aa)
RABIFRAB interacting factor; Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport (123 aa)
BET3LBET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) (181 aa)
TRAPPC3trafficking protein particle complex 3; May play a role in vesicular transport from endoplasmic reticulum to Golgi (180 aa)
GOLGA1golgin A1; Probably involved in maintaining Golgi structure (767 aa)
RGP1RGP1 retrograde golgi transport homolog (S. cerevisiae) (391 aa)
TMF1TATA element modulatory factor 1; Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes- one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP) (1093 aa)
TGOLN2trans-golgi network protein 2 (453 aa)
VPS53vacuolar protein sorting 53 homolog (S. cerevisiae); May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (832 aa)
RAB40BRAB40B, member RAS oncogene family; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (278 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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