12 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	SART3	squamous cell carcinoma antigen recognized by T cells 3; Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication (963 aa)
	TFG	TRK-fused gene (400 aa)
	HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA (825 aa)
	RPP14	ribonuclease P/MRP 14kDa subunit; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (124 aa)
	NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin) (294 aa)
	RPP25	ribonuclease P/MRP 25kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP. This subunit binds to RNA (199 aa)
	C3orf17	chromosome 3 open reading frame 17 (567 aa)
	GPRASP2	G protein-coupled receptor associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors (838 aa)
	G3BP2	GTPase activating protein (SH3 domain) binding protein 2; Probable scaffold protein that may be involved in mRNA transport (Potential) (482 aa)
	RPP40	ribonuclease P/MRP 40kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (363 aa)
	RPP30	ribonuclease P/MRP 30kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (322 aa)
	POP4	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P (220 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3orf17	G3BP2	ENSP00000320251	ENSP00000352738	chromosome 3 open reading frame 17	GTPase activating protein (SH3 domain) binding protein 2; Probable scaffold protein that may be involved in mRNA transport (Potential)	0.740
C3orf17	GPRASP2	ENSP00000320251	ENSP00000339057	chromosome 3 open reading frame 17	G protein-coupled receptor associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors	0.481
C3orf17	SART3	ENSP00000320251	ENSP00000228284	chromosome 3 open reading frame 17	squamous cell carcinoma antigen recognized by T cells 3; Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication	0.740
G3BP2	C3orf17	ENSP00000352738	ENSP00000320251	GTPase activating protein (SH3 domain) binding protein 2; Probable scaffold protein that may be involved in mRNA transport (Potential)	chromosome 3 open reading frame 17	0.740
GPRASP2	C3orf17	ENSP00000339057	ENSP00000320251	G protein-coupled receptor associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors	chromosome 3 open reading frame 17	0.481
HNRNPU	NPM1	ENSP00000283179	ENSP00000296930	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.783
NPM1	HNRNPU	ENSP00000296930	ENSP00000283179	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA	0.783
NPM1	TFG	ENSP00000296930	ENSP00000240851	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	TRK-fused gene	0.513
POP4	RPP14	ENSP00000465213	ENSP00000295959	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P	ribonuclease P/MRP 14kDa subunit; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends	0.999
POP4	RPP25	ENSP00000465213	ENSP00000317691	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P	ribonuclease P/MRP 25kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP. This subunit binds to RNA	0.999
POP4	RPP30	ENSP00000465213	ENSP00000389182	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P	ribonuclease P/MRP 30kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends	0.998
POP4	RPP40	ENSP00000465213	ENSP00000369391	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P	ribonuclease P/MRP 40kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends	0.881
RPP14	POP4	ENSP00000295959	ENSP00000465213	ribonuclease P/MRP 14kDa subunit; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P	0.999
RPP14	RPP25	ENSP00000295959	ENSP00000317691	ribonuclease P/MRP 14kDa subunit; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends	ribonuclease P/MRP 25kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP. This subunit binds to RNA	0.999
RPP14	RPP30	ENSP00000295959	ENSP00000389182	ribonuclease P/MRP 14kDa subunit; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends	ribonuclease P/MRP 30kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends	0.999
RPP14	RPP40	ENSP00000295959	ENSP00000369391	ribonuclease P/MRP 14kDa subunit; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends	ribonuclease P/MRP 40kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends	0.999
RPP25	POP4	ENSP00000317691	ENSP00000465213	ribonuclease P/MRP 25kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP. This subunit binds to RNA	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P	0.999
RPP25	RPP14	ENSP00000317691	ENSP00000295959	ribonuclease P/MRP 25kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP. This subunit binds to RNA	ribonuclease P/MRP 14kDa subunit; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends	0.999
RPP25	RPP30	ENSP00000317691	ENSP00000389182	ribonuclease P/MRP 25kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP. This subunit binds to RNA	ribonuclease P/MRP 30kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends	0.881
RPP25	RPP40	ENSP00000317691	ENSP00000369391	ribonuclease P/MRP 25kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP. This subunit binds to RNA	ribonuclease P/MRP 40kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends	0.929

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