node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | HTRA3 | ENSP00000253792 | ENSP00000303766 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | HtrA serine peptidase 3; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization | 0.619 |
ACLY | TYSND1 | ENSP00000253792 | ENSP00000287078 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | trypsin domain containing 1; Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta- oxidation of fatty acids | 0.619 |
ACLY | UBC | ENSP00000253792 | ENSP00000344818 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | ubiquitin C | 0.687 |
HTRA3 | ACLY | ENSP00000303766 | ENSP00000253792 | HtrA serine peptidase 3; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.619 |
HTRA3 | UBC | ENSP00000303766 | ENSP00000344818 | HtrA serine peptidase 3; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization | ubiquitin C | 0.663 |
PEX19 | PXMP2 | ENSP00000357051 | ENSP00000321271 | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | peroxisomal membrane protein 2, 22kDa; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane | 0.923 |
PEX19 | TOMM20 | ENSP00000357051 | ENSP00000355566 | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity) | 0.695 |
PEX19 | TYSND1 | ENSP00000357051 | ENSP00000287078 | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | trypsin domain containing 1; Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta- oxidation of fatty acids | 0.475 |
PEX19 | UBC | ENSP00000357051 | ENSP00000344818 | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | ubiquitin C | 0.947 |
PXMP2 | PEX19 | ENSP00000321271 | ENSP00000357051 | peroxisomal membrane protein 2, 22kDa; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | 0.923 |
PXMP2 | SIVA1 | ENSP00000321271 | ENSP00000329213 | peroxisomal membrane protein 2, 22kDa; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane | SIVA1, apoptosis-inducing factor; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis | 0.598 |
RTN1 | RTN3 | ENSP00000267484 | ENSP00000344106 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | reticulon 3 | 0.762 |
RTN3 | RTN1 | ENSP00000344106 | ENSP00000267484 | reticulon 3 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | 0.762 |
RTN3 | RTN4 | ENSP00000344106 | ENSP00000337838 | reticulon 3 | reticulon 4 | 0.903 |
RTN3 | UBC | ENSP00000344106 | ENSP00000344818 | reticulon 3 | ubiquitin C | 0.866 |
RTN4 | RTN3 | ENSP00000337838 | ENSP00000344106 | reticulon 4 | reticulon 3 | 0.903 |
RTN4 | UBC | ENSP00000337838 | ENSP00000344818 | reticulon 4 | ubiquitin C | 0.902 |
SIVA1 | PXMP2 | ENSP00000329213 | ENSP00000321271 | SIVA1, apoptosis-inducing factor; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis | peroxisomal membrane protein 2, 22kDa; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane | 0.598 |
SIVA1 | UBC | ENSP00000329213 | ENSP00000344818 | SIVA1, apoptosis-inducing factor; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis | ubiquitin C | 0.721 |
SLC25A20 | UBC | ENSP00000326305 | ENSP00000344818 | solute carrier family 25 (carnitine/acylcarnitine translocase), member 20; Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway | ubiquitin C | 0.411 |