8 items (Homo sapiens) - STRING network view

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Your Input:
	EGFR	epidermal growth factor receptor (1210 aa)
	DCBLD2	discoidin, CUB and LCCL domain containing 2 (775 aa)
	SEMA4B	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B; Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity) (837 aa)
	TRAF6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...] (522 aa)
	UBC	ubiquitin C (685 aa)
	CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals (303 aa)
	FYN	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...] (537 aa)
	ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro (326 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRKL	DCBLD2	ENSP00000346300	ENSP00000321573	v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals	discoidin, CUB and LCCL domain containing 2	0.587
CRKL	EGFR	ENSP00000346300	ENSP00000275493	v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals	epidermal growth factor receptor	0.988
CRKL	FYN	ENSP00000346300	ENSP00000346671	v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	0.982
CRKL	UBC	ENSP00000346300	ENSP00000344818	v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals	ubiquitin C	0.927
DCBLD2	CRKL	ENSP00000321573	ENSP00000346300	discoidin, CUB and LCCL domain containing 2	v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals	0.587
DCBLD2	EGFR	ENSP00000321573	ENSP00000275493	discoidin, CUB and LCCL domain containing 2	epidermal growth factor receptor	0.576
DCBLD2	FYN	ENSP00000321573	ENSP00000346671	discoidin, CUB and LCCL domain containing 2	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	0.576
DCBLD2	SEMA4B	ENSP00000321573	ENSP00000332204	discoidin, CUB and LCCL domain containing 2	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B; Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity)	0.609
DCBLD2	TRAF6	ENSP00000321573	ENSP00000337853	discoidin, CUB and LCCL domain containing 2	TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...]	0.576
DCBLD2	UBC	ENSP00000321573	ENSP00000344818	discoidin, CUB and LCCL domain containing 2	ubiquitin C	0.795
EGFR	CRKL	ENSP00000275493	ENSP00000346300	epidermal growth factor receptor	v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals	0.988
EGFR	DCBLD2	ENSP00000275493	ENSP00000321573	epidermal growth factor receptor	discoidin, CUB and LCCL domain containing 2	0.576
EGFR	ELAVL1	ENSP00000275493	ENSP00000385269	epidermal growth factor receptor	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro	0.446
EGFR	FYN	ENSP00000275493	ENSP00000346671	epidermal growth factor receptor	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	0.932
EGFR	TRAF6	ENSP00000275493	ENSP00000337853	epidermal growth factor receptor	TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...]	0.863
EGFR	UBC	ENSP00000275493	ENSP00000344818	epidermal growth factor receptor	ubiquitin C	0.999
ELAVL1	EGFR	ENSP00000385269	ENSP00000275493	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro	epidermal growth factor receptor	0.446
ELAVL1	UBC	ENSP00000385269	ENSP00000344818	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro	ubiquitin C	0.998
FYN	CRKL	ENSP00000346671	ENSP00000346300	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals	0.982
FYN	DCBLD2	ENSP00000346671	ENSP00000321573	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	discoidin, CUB and LCCL domain containing 2	0.576

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