node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ECI2 | HIBCH | ENSP00000369461 | ENSP00000352706 | enoyl-CoA delta isomerase 2 | 3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA | 0.640 |
GGT5 | GGT6 | ENSP00000381340 | ENSP00000458307 | gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4) | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | 0.770 |
GGT6 | GGT5 | ENSP00000458307 | ENSP00000381340 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4) | 0.770 |
GGT6 | GGTLC1 | ENSP00000458307 | ENSP00000278765 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | gamma-glutamyltransferase light chain 1 | 0.760 |
GGT6 | GGTLC2 | ENSP00000458307 | ENSP00000419751 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | gamma-glutamyltransferase light chain 2 | 0.744 |
GGTLC1 | GGT6 | ENSP00000278765 | ENSP00000458307 | gamma-glutamyltransferase light chain 1 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | 0.760 |
GGTLC2 | GGT6 | ENSP00000419751 | ENSP00000458307 | gamma-glutamyltransferase light chain 2 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | 0.744 |
HIBCH | ECI2 | ENSP00000352706 | ENSP00000369461 | 3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA | enoyl-CoA delta isomerase 2 | 0.640 |
ITGB2 | VNN2 | ENSP00000303242 | ENSP00000322276 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration dur [...] | vanin 2 | 0.629 |
PACSIN1 | PACSIN2 | ENSP00000244458 | ENSP00000263246 | protein kinase C and casein kinase substrate in neurons 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the [...] | protein kinase C and casein kinase substrate in neurons 2; Plays a role in the formation of normal, flask-shaped caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. Plays a role in intracellular vesicle-mediated transport. Binds to membranes via its F-BAR domain and promotes membrane tubulation. Plays a role in the internalization of cell-surface receptors. Is not required for internalization of EGFR after EGF stimulus, but contributes to the internalization of EGFR in the absence of EGF stimulus | 0.978 |
PACSIN1 | PACSIN3 | ENSP00000244458 | ENSP00000298838 | protein kinase C and casein kinase substrate in neurons 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the [...] | protein kinase C and casein kinase substrate in neurons 3; May play a role in endocytosis (By similarity) | 0.808 |
PACSIN2 | PACSIN1 | ENSP00000263246 | ENSP00000244458 | protein kinase C and casein kinase substrate in neurons 2; Plays a role in the formation of normal, flask-shaped caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. Plays a role in intracellular vesicle-mediated transport. Binds to membranes via its F-BAR domain and promotes membrane tubulation. Plays a role in the internalization of cell-surface receptors. Is not required for internalization of EGFR after EGF stimulus, but contributes to the internalization of EGFR in the absence of EGF stimulus | protein kinase C and casein kinase substrate in neurons 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the [...] | 0.978 |
PACSIN2 | PACSIN3 | ENSP00000263246 | ENSP00000298838 | protein kinase C and casein kinase substrate in neurons 2; Plays a role in the formation of normal, flask-shaped caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. Plays a role in intracellular vesicle-mediated transport. Binds to membranes via its F-BAR domain and promotes membrane tubulation. Plays a role in the internalization of cell-surface receptors. Is not required for internalization of EGFR after EGF stimulus, but contributes to the internalization of EGFR in the absence of EGF stimulus | protein kinase C and casein kinase substrate in neurons 3; May play a role in endocytosis (By similarity) | 0.585 |
PACSIN3 | PACSIN1 | ENSP00000298838 | ENSP00000244458 | protein kinase C and casein kinase substrate in neurons 3; May play a role in endocytosis (By similarity) | protein kinase C and casein kinase substrate in neurons 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the [...] | 0.808 |
PACSIN3 | PACSIN2 | ENSP00000298838 | ENSP00000263246 | protein kinase C and casein kinase substrate in neurons 3; May play a role in endocytosis (By similarity) | protein kinase C and casein kinase substrate in neurons 2; Plays a role in the formation of normal, flask-shaped caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. Plays a role in intracellular vesicle-mediated transport. Binds to membranes via its F-BAR domain and promotes membrane tubulation. Plays a role in the internalization of cell-surface receptors. Is not required for internalization of EGFR after EGF stimulus, but contributes to the internalization of EGFR in the absence of EGF stimulus | 0.585 |
PANK3 | VNN2 | ENSP00000239231 | ENSP00000322276 | pantothenate kinase 3; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | vanin 2 | 0.905 |
PANK4 | VNN2 | ENSP00000367727 | ENSP00000322276 | pantothenate kinase 4; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | vanin 2 | 0.900 |
VNN2 | ITGB2 | ENSP00000322276 | ENSP00000303242 | vanin 2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration dur [...] | 0.629 |
VNN2 | PANK3 | ENSP00000322276 | ENSP00000239231 | vanin 2 | pantothenate kinase 3; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | 0.905 |
VNN2 | PANK4 | ENSP00000322276 | ENSP00000367727 | vanin 2 | pantothenate kinase 4; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | 0.900 |