Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | IGFBP5 | insulin-like growth factor binding protein 5; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors (272 aa) | ||
 | IL6 | interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] (212 aa) | ||
 | PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on ’Thr-14’. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on ’Tyr-15’ to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development (499 aa) | ||
 | NUCB1 | nucleobindin 1; Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity) (461 aa) | ||
 | STC2 | stanniocalcin 2; Has an anti-hypocalcemic action on calcium and phosphate homeostasis (302 aa) | ||
 | IGFBP1 | insulin-like growth factor binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (259 aa) | ||
 | SPARCL1 | SPARC-like 1 (hevin) (664 aa) | ||
 | ALB | albumin (609 aa) | ||
 | PCSK9 | proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members- low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (692 aa) | ||
 | FOS | FBJ murine osteosarcoma viral oncogene homolog; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell p [...] (380 aa) | ||
 | FGA | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation (866 aa) | ||
 | PROP1 | PROP paired-like homeobox 1; Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes (226 aa) | ||
 | AMBN | ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel (447 aa) | ||
 | FAM20C | family with sequence similarity 20, member C; Calcium-binding kinase that phosphorylates the caseins and several secreted proteins implicated in biomineralization, including the secretory calcium binding phosphoproteins (SCPP). Preferencially phosphorylates its targets within the S-x-E/pS motif (584 aa) | ||
 | AMTN | amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel (209 aa) | ||
 | CSN2 | casein beta; Important role in determination of the surface properties of the casein micelles (226 aa) | ||
 | FN1 | fibronectin 1 (2477 aa) | ||
 | F5 | coagulation factor V (proaccelerin, labile factor); Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin (2224 aa) | ||
 | AMELX | amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel (205 aa) | ||
 | IGFBP3 | insulin-like growth factor binding protein 3; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (297 aa) | ||
 | SPP1 | secreted phosphoprotein 1 (314 aa) | ||
 | ENAM | enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation (1142 aa) | ||
 | AHSG | alpha-2-HS-glycoprotein; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (367 aa) | ||
 | PRH1 | proline-rich protein HaeIII subfamily 1 (166 aa) | ||
 | CALU | calumenin (323 aa) | ||
 | FAM20A | family with sequence similarity 20, member A (541 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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