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VSNL1 VSNL1 NCS1 NCS1 RBPMS RBPMS ALKBH4 ALKBH4 HDC HDC SEC22A SEC22A ARNT2 ARNT2 EIF4ENIF1 EIF4ENIF1 RHOXF2 RHOXF2 DTX2 DTX2 HPCAL4 HPCAL4 NOTCH2 NOTCH2 NCALD NCALD DTX1 DTX1 DTX3 DTX3 WWP1 WWP1 ITCH ITCH NOTCH3 NOTCH3 WWP2 WWP2 UBE2D4 UBE2D4 NOTCH1 NOTCH1 NOTCH4 NOTCH4 UBC UBC UBE2D1 UBE2D1 HPCAL1 HPCAL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
NCALDneurocalcin delta; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (193 aa)
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative); Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer ’Lys-11’ and ’Lys-48’-linked polyubiquitination (147 aa)
NOTCH2notch 2 (2471 aa)
DTX1deltex homolog 1 (Drosophila); Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiti [...] (620 aa)
NOTCH3notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) (2321 aa)
WWP1WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...] (922 aa)
HDChistidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine (662 aa)
NOTCH1notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] (2555 aa)
ALKBH4alkB, alkylation repair homolog 4 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity) (302 aa)
VSNL1visinin-like 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner (By similarity) (191 aa)
ARNT2aryl-hydrocarbon receptor nuclear translocator 2; Specifically recognizes the xenobiotic response element (XRE) (717 aa)
SEC22ASEC22 vesicle trafficking protein homolog A (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (By similarity) (307 aa)
HPCAL1hippocalcin-like 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation (193 aa)
DTX2deltex homolog 2 (Drosophila); Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (622 aa)
EIF4ENIF1eukaryotic translation initiation factor 4E nuclear import factor 1; Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism (985 aa)
DTX3deltex homolog 3 (Drosophila); Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (347 aa)
RBPMSRNA binding protein with multiple splicing; Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA (219 aa)
UBCubiquitin C (685 aa)
WWP2WW domain containing E3 ubiquitin protein ligase 2 (870 aa)
RHOXF2Rhox homeobox family, member 2 (288 aa)
NCS1neuronal calcium sensor 1; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity) (190 aa)
HPCAL4hippocalcin like 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation (By similarity) (191 aa)
UBE2D1ubiquitin-conjugating enzyme E2D 1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyu [...] (147 aa)
ITCHitchy E3 ubiquitin protein ligase (862 aa)
NOTCH4notch 4 (2003 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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