Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | RPL18A | ribosomal protein L18a (176 aa) | ||
 | RPL19 | ribosomal protein L19 (196 aa) | ||
 | WDR18 | WD repeat domain 18; May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (432 aa) | ||
 | RPL27 | ribosomal protein L27 (136 aa) | ||
 | RPL35 | ribosomal protein L35 (123 aa) | ||
 | RPL8 | ribosomal protein L8 (257 aa) | ||
 | RPL26L1 | ribosomal protein L26-like 1 (145 aa) | ||
 | RPL37 | ribosomal protein L37; Binds to the 23S rRNA (By similarity) (97 aa) | ||
 | RPL30 | ribosomal protein L30 (115 aa) | ||
 | RPL39L | ribosomal protein L39-like (51 aa) | ||
 | RPL4 | ribosomal protein L4 (427 aa) | ||
 | RPLP2 | ribosomal protein, large, P2; Plays an important role in the elongation step of protein synthesis (115 aa) | ||
 | ISG20L2 | interferon stimulated exonuclease gene 20kDa-like 2; 3’-> 5’-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3’-end containing a free hydroxyl group (353 aa) | ||
 | RPL10 | ribosomal protein L10 (214 aa) | ||
 | RPL36AL | ribosomal protein L36a-like (106 aa) | ||
 | RPL27A | ribosomal protein L27a (148 aa) | ||
 | RPL22L1 | ribosomal protein L22-like 1 (122 aa) | ||
 | RPL7A | ribosomal protein L7a (266 aa) | ||
 | RPL10A | ribosomal protein L10a (217 aa) | ||
 | NOL9 | nucleolar protein 9; Polynucleotide 5’-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5’-kinase activities. Probably binds RNA (702 aa) | ||
 | RPL23 | ribosomal protein L23 (140 aa) | ||
 | RPL32 | ribosomal protein L32 (135 aa) | ||
 | SENP3 | SUMO1/sentrin/SMT3 specific peptidase 3; Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation stat [...] (574 aa) | ||
 | RPL37A | ribosomal protein L37a (92 aa) | ||
 | RPL41 | ribosomal protein L41 (25 aa) | ||
 | RPL17 | ribosomal protein L17 (184 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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