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NKX1-1 NKX1-1 RGPD4 RGPD4 RGPD2 RGPD2 CRIPAK CRIPAK ZNF136 ZNF136 CCDC85B CCDC85B RGPD8 RGPD8 ESR1 ESR1 ZNF131 ZNF131 PAK1 PAK1 RANBP2 RANBP2 SETMAR SETMAR RANBP1 RANBP1 SETD2 SETD2 RGPD1 RGPD1 RGPD5 RGPD5 MLL4 MLL4 SPTBN4 SPTBN4 MLL3 MLL3 ZNF536 ZNF536 CCDC85C CCDC85C RGPD6 RGPD6 RGPD3 RGPD3 CCDC85A CCDC85A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RGPD5RANBP2-like and GRIP domain containing 5 (1765 aa)
ESR1estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] (595 aa)
MLL4Histone-lysine N-methyltransferase MLL4 ; Histone methyltransferase. Methylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds r [...] (2715 aa)
MLL3myeloid/lymphoid or mixed-lineage leukemia 3; Histone methyltransferase. Methylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder (4911 aa)
SPTBN4spectrin, beta, non-erythrocytic 4 (2564 aa)
PAK1p21 protein (Cdc42/Rac)-activated kinase 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby [...] (553 aa)
RANBP2RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB (3224 aa)
ZNF131zinc finger protein 131; Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ERalpha signaling (589 aa)
RGPD8RANBP2-like and GRIP domain containing 8 (1765 aa)
CCDC85Bcoiled-coil domain containing 85B; Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (202 aa)
CRIPAKcysteine-rich PAK1 inhibitor; Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence (446 aa)
RANBP1RAN binding protein 1; Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane (201 aa)
RGPD6RANBP2-like and GRIP domain containing 6 (1765 aa)
ZNF136zinc finger protein 136; May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain (540 aa)
ZNF536zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ (1300 aa)
CCDC85Ccoiled-coil domain containing 85C; May play an important role in cortical development, especially in the maintenance of radial glia (By similarity) (419 aa)
SETMARSET domain and mariner transposase fusion gene; Histone methyltransferase that methylates ’Lys-4’ and ’Lys-36’ of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 ’Lys-36’. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5’-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA (684 aa)
RGPD2RANBP2-like and GRIP domain containing 2 (1756 aa)
RGPD1RANBP2-like and GRIP domain containing 1 (1756 aa)
CCDC85Acoiled-coil domain containing 85A (553 aa)
RGPD3RANBP2-like and GRIP domain containing 3 (1758 aa)
SETD2SET domain containing 2 (2564 aa)
RGPD4RANBP2-like and GRIP domain containing 4 (1758 aa)
NKX1-1NK1 homeobox 1 (411 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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