node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CREBBP | RPA2 | ENSP00000262367 | ENSP00000363021 | CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 | replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage | 0.556 |
CREBBP | SERTAD3 | ENSP00000262367 | ENSP00000325414 | CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 | SERTA domain containing 3; Strong transcriptional coactivator | 0.576 |
CREBBP | UBC | ENSP00000262367 | ENSP00000344818 | CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 | ubiquitin C | 0.884 |
FBXO44 | SERTAD3 | ENSP00000251547 | ENSP00000325414 | F-box protein 44; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex | SERTA domain containing 3; Strong transcriptional coactivator | 0.576 |
NDN | UBC | ENSP00000332643 | ENSP00000344818 | necdin homolog (mouse); Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity) | ubiquitin C | 0.832 |
RPA2 | CREBBP | ENSP00000363021 | ENSP00000262367 | replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage | CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 | 0.556 |
RPA2 | SERTAD3 | ENSP00000363021 | ENSP00000325414 | replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage | SERTA domain containing 3; Strong transcriptional coactivator | 0.936 |
RPA2 | UBC | ENSP00000363021 | ENSP00000344818 | replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage | ubiquitin C | 0.900 |
SERTAD3 | CREBBP | ENSP00000325414 | ENSP00000262367 | SERTA domain containing 3; Strong transcriptional coactivator | CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 | 0.576 |
SERTAD3 | FBXO44 | ENSP00000325414 | ENSP00000251547 | SERTA domain containing 3; Strong transcriptional coactivator | F-box protein 44; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex | 0.576 |
SERTAD3 | RPA2 | ENSP00000325414 | ENSP00000363021 | SERTA domain containing 3; Strong transcriptional coactivator | replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage | 0.936 |
SERTAD3 | SPG11 | ENSP00000325414 | ENSP00000261866 | SERTA domain containing 3; Strong transcriptional coactivator | spastic paraplegia 11 (autosomal recessive) | 0.613 |
SERTAD3 | USHBP1 | ENSP00000325414 | ENSP00000252597 | SERTA domain containing 3; Strong transcriptional coactivator | Usher syndrome 1C binding protein 1 | 0.499 |
SPG11 | SERTAD3 | ENSP00000261866 | ENSP00000325414 | spastic paraplegia 11 (autosomal recessive) | SERTA domain containing 3; Strong transcriptional coactivator | 0.613 |
SPG11 | UBC | ENSP00000261866 | ENSP00000344818 | spastic paraplegia 11 (autosomal recessive) | ubiquitin C | 0.849 |
UBC | CREBBP | ENSP00000344818 | ENSP00000262367 | ubiquitin C | CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 | 0.884 |
UBC | NDN | ENSP00000344818 | ENSP00000332643 | ubiquitin C | necdin homolog (mouse); Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity) | 0.832 |
UBC | RPA2 | ENSP00000344818 | ENSP00000363021 | ubiquitin C | replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage | 0.900 |
UBC | SPG11 | ENSP00000344818 | ENSP00000261866 | ubiquitin C | spastic paraplegia 11 (autosomal recessive) | 0.849 |
USHBP1 | SERTAD3 | ENSP00000252597 | ENSP00000325414 | Usher syndrome 1C binding protein 1 | SERTA domain containing 3; Strong transcriptional coactivator | 0.499 |