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EIF5 | eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (431 aa) | |||
RPL19 | ribosomal protein L19 (196 aa) | |||
EIF3J | eukaryotic translation initiation factor 3, subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] (258 aa) | |||
CNOT6 | CCR4-NOT transcription complex, subunit 6; Poly(A) nuclease with 3’-5’ RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein- coding determinant of instability (mCRD) of the FOS gene in the cyto [...] (557 aa) | |||
EIF4A3 | eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] (411 aa) | |||
RQCD1 | RCD1 required for cell differentiation1 homolog (S. pombe); Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such a [...] (299 aa) | |||
EIF4A1 | eukaryotic translation initiation factor 4A1; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (406 aa) | |||
RPS23 | ribosomal protein S23 (143 aa) | |||
EIF3F | eukaryotic translation initiation factor 3, subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] (357 aa) | |||
RPS15A | ribosomal protein S15a (130 aa) | |||
CNOT1 | CCR4-NOT transcription complex, subunit 1 (2376 aa) | |||
EIF4A2 | eukaryotic translation initiation factor 4A2; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (407 aa) | |||
CNOT10 | CCR4-NOT transcription complex, subunit 10 (744 aa) | |||
RPS2 | ribosomal protein S2 (293 aa) | |||
UBC | ubiquitin C (685 aa) | |||
RPL21 | ribosomal protein L21 (160 aa) | |||
RPL39 | ribosomal protein L39 (51 aa) | |||
EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3; Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1 (1591 aa) | |||
PAN3 | PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) (887 aa) | |||
RPL24 | ribosomal protein L24 (157 aa) | |||
RPL34 | ribosomal protein L34 (117 aa) | |||
RPL31 | ribosomal protein L31 (128 aa) | |||
PARN | poly(A)-specific ribonuclease; 3’-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3’-end poly(A) tail and the 5’-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-med [...] (639 aa) | |||
EIF3H | eukaryotic translation initiation factor 3, subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] (352 aa) | |||
CNOT4 | CCR4-NOT transcription complex, subunit 4 (713 aa) | |||
RPS19 | ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits (145 aa) |