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HIST1H3D HIST1H3D HIST1H3E HIST1H3E HIST1H3J HIST1H3J HIST2H3A HIST2H3A H3F3C H3F3C HIST1H3A HIST1H3A HIST1H3B HIST1H3B HIST3H3 HIST3H3 HIST1H3F HIST1H3F HIST1H4L HIST1H4L HIST1H4I HIST1H4I HIST2H3C HIST2H3C PDHX PDHX DLAT DLAT HIST1H3G HIST1H3G H3F3B H3F3B HIST2H3D HIST2H3D HIST1H3I HIST1H3I HIST1H3H HIST1H3H H3F3A H3F3A CENPA CENPA SSBP1 SSBP1 CDIPT CDIPT HIST1H3C HIST1H3C CRLS1 CRLS1 SLC47A2 SLC47A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (213 aa)
PDHXpyruvate dehydrogenase complex, component X; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex (501 aa)
HIST1H3Bhistone cluster 1, H3b (136 aa)
H3F3BH3 histone, family 3B (H3.3B); Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play [...] (136 aa)
SSBP1single-stranded DNA binding protein 1, mitochondrial; This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA (148 aa)
DLATdihydrolipoamide S-acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle (647 aa)
SLC47A2solute carrier family 47, member 2; Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes (602 aa)
HIST1H3Ihistone cluster 1, H3i (136 aa)
HIST2H3Dhistone cluster 2, H3d (136 aa)
CENPAcentromere protein A; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro) (140 aa)
H3F3CH3 histone, family 3C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes (135 aa)
HIST1H4Ihistone cluster 1, H4i (103 aa)
HIST1H4Lhistone cluster 1, H4l (103 aa)
HIST1H3Ahistone cluster 1, H3a (136 aa)
HIST1H3Jhistone cluster 1, H3j (136 aa)
HIST1H3Ehistone cluster 1, H3e (136 aa)
HIST3H3histone cluster 3, H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (136 aa)
H3F3AH3 histone, family 3A; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a centra [...] (136 aa)
HIST2H3Chistone cluster 2, H3c (136 aa)
HIST1H3Hhistone cluster 1, H3h (136 aa)
HIST1H3Dhistone cluster 1, H3d (136 aa)
CRLS1cardiolipin synthase 1; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (301 aa)
HIST2H3Ahistone cluster 2, H3a (136 aa)
HIST1H3Chistone cluster 1, H3c (136 aa)
HIST1H3Ghistone cluster 1, H3g (136 aa)
HIST1H3Fhistone cluster 1, H3f (136 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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