node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ECHDC1 | UBC | ENSP00000436585 | ENSP00000344818 | enoyl CoA hydratase domain containing 1 | ubiquitin C | 0.721 |
ECHS1 | UBC | ENSP00000357535 | ENSP00000344818 | enoyl CoA hydratase, short chain, 1, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate | ubiquitin C | 0.802 |
NIF3L1 | NT5DC1 | ENSP00000386394 | ENSP00000326858 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 5’-nucleotidase domain containing 1 | 0.644 |
NIF3L1 | UBC | ENSP00000386394 | ENSP00000344818 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | ubiquitin C | 0.483 |
NT5DC1 | NIF3L1 | ENSP00000326858 | ENSP00000386394 | 5’-nucleotidase domain containing 1 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 0.644 |
NT5DC1 | SRM | ENSP00000326858 | ENSP00000366156 | 5’-nucleotidase domain containing 1 | spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine | 0.644 |
NT5DC1 | UBA3 | ENSP00000326858 | ENSP00000354340 | 5’-nucleotidase domain containing 1 | ubiquitin-like modifier activating enzyme 3; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression | 0.644 |
NT5DC1 | UBC | ENSP00000326858 | ENSP00000344818 | 5’-nucleotidase domain containing 1 | ubiquitin C | 0.721 |
NT5DC1 | UCHL3 | ENSP00000326858 | ENSP00000366819 | 5’-nucleotidase domain containing 1 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards ’Lys-48’-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGF [...] | 0.644 |
SRM | NT5DC1 | ENSP00000366156 | ENSP00000326858 | spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine | 5’-nucleotidase domain containing 1 | 0.644 |
SRM | UBC | ENSP00000366156 | ENSP00000344818 | spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine | ubiquitin C | 0.944 |
UBA3 | NT5DC1 | ENSP00000354340 | ENSP00000326858 | ubiquitin-like modifier activating enzyme 3; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression | 5’-nucleotidase domain containing 1 | 0.644 |
UBA3 | UBC | ENSP00000354340 | ENSP00000344818 | ubiquitin-like modifier activating enzyme 3; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression | ubiquitin C | 0.986 |
UBA3 | UCHL3 | ENSP00000354340 | ENSP00000366819 | ubiquitin-like modifier activating enzyme 3; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards ’Lys-48’-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGF [...] | 0.424 |
UBC | ECHDC1 | ENSP00000344818 | ENSP00000436585 | ubiquitin C | enoyl CoA hydratase domain containing 1 | 0.721 |
UBC | ECHS1 | ENSP00000344818 | ENSP00000357535 | ubiquitin C | enoyl CoA hydratase, short chain, 1, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate | 0.802 |
UBC | NIF3L1 | ENSP00000344818 | ENSP00000386394 | ubiquitin C | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 0.483 |
UBC | NT5DC1 | ENSP00000344818 | ENSP00000326858 | ubiquitin C | 5’-nucleotidase domain containing 1 | 0.721 |
UBC | SRM | ENSP00000344818 | ENSP00000366156 | ubiquitin C | spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine | 0.944 |
UBC | UBA3 | ENSP00000344818 | ENSP00000354340 | ubiquitin C | ubiquitin-like modifier activating enzyme 3; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression | 0.986 |