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NDRG2 NDRG2 YIPF6 YIPF6 TMEM128 TMEM128 TMEM107 TMEM107 TMEM134 TMEM134 GPM6B GPM6B C14orf1 C14orf1 TMEM14A TMEM14A CLN8 CLN8 PLP1 PLP1 ARL6IP5 ARL6IP5 RRP15 RRP15 PDIA6 PDIA6 TUBB4A TUBB4A TMEM147 TMEM147 STX8 STX8 VAPA VAPA UBC UBC RTN4 RTN4 CYB5B CYB5B GABARAPL2 GABARAPL2 MTX1 MTX1 TMEM11 TMEM11 ZUFSP ZUFSP BNIP3 BNIP3 TRIB1 TRIB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
GABARAPL2GABA(A) receptor-associated protein-like 2; Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (By similarity) (117 aa)
TMEM14Atransmembrane protein 14A (99 aa)
TMEM147transmembrane protein 147 (224 aa)
TMEM128transmembrane protein 128 (141 aa)
C14orf1chromosome 14 open reading frame 1 (140 aa)
TUBB4Atubulin, beta 4A class IVa; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) (444 aa)
PDIA6protein disulfide isomerase family A, member 6; May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (440 aa)
ARL6IP5ADP-ribosylation-like factor 6 interacting protein 5; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic (By similarity) (188 aa)
NDRG2NDRG family member 2 (371 aa)
PLP1proteolipid protein 1; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin (277 aa)
STX8syntaxin 8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER (236 aa)
CYB5Bcytochrome b5 type B (outer mitochondrial membrane); Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases (By similarity) (150 aa)
TRIB1tribbles homolog 1 (Drosophila); Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity (372 aa)
TMEM134transmembrane protein 134 (195 aa)
TMEM107transmembrane protein 107; Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity) (146 aa)
GPM6Bglycoprotein M6B; May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake (328 aa)
TMEM11transmembrane protein 11; Plays a role in mitochondrial morphogenesis (192 aa)
CLN8ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation); Could play a role in cell proliferation during neuronal differentiation and in protection against cell death (286 aa)
RTN4reticulon 4 (1192 aa)
UBCubiquitin C (685 aa)
VAPAVAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking (294 aa)
RRP15ribosomal RNA processing 15 homolog (S. cerevisiae) (282 aa)
MTX1metaxin 1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity) (466 aa)
ZUFSPzinc finger with UFM1-specific peptidase domain (578 aa)
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane [...] (194 aa)
YIPF6Yip1 domain family, member 6 (236 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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