node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL2 | IL2RA | ENSP00000226730 | ENSP00000369293 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | interleukin 2 receptor, alpha; Receptor for interleukin-2 | 0.999 |
IL2 | IL2RB | ENSP00000226730 | ENSP00000216223 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | 0.999 |
IL2 | IL2RG | ENSP00000226730 | ENSP00000363318 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | 0.999 |
IL2 | TNFRSF18 | ENSP00000226730 | ENSP00000328207 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | tumor necrosis factor receptor superfamily, member 18; Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway | 0.925 |
IL2RA | IL2 | ENSP00000369293 | ENSP00000226730 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.999 |
IL2RA | IL2RB | ENSP00000369293 | ENSP00000216223 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | 0.999 |
IL2RA | IL2RG | ENSP00000369293 | ENSP00000363318 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | 0.996 |
IL2RA | TNFRSF18 | ENSP00000369293 | ENSP00000328207 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | tumor necrosis factor receptor superfamily, member 18; Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway | 0.956 |
IL2RA | TNFSF18 | ENSP00000369293 | ENSP00000385470 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | tumor necrosis factor (ligand) superfamily, member 18; Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B | 0.408 |
IL2RB | IL2 | ENSP00000216223 | ENSP00000226730 | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.999 |
IL2RB | IL2RA | ENSP00000216223 | ENSP00000369293 | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | 0.999 |
IL2RB | IL2RG | ENSP00000216223 | ENSP00000363318 | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | 0.999 |
IL2RB | TNFRSF18 | ENSP00000216223 | ENSP00000328207 | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | tumor necrosis factor receptor superfamily, member 18; Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway | 0.930 |
IL2RG | IL2 | ENSP00000363318 | ENSP00000226730 | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.999 |
IL2RG | IL2RA | ENSP00000363318 | ENSP00000369293 | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | interleukin 2 receptor, alpha; Receptor for interleukin-2 | 0.996 |
IL2RG | IL2RB | ENSP00000363318 | ENSP00000216223 | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | 0.999 |
IL2RG | TNFRSF18 | ENSP00000363318 | ENSP00000328207 | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | tumor necrosis factor receptor superfamily, member 18; Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway | 0.919 |
RARA | SPI1 | ENSP00000254066 | ENSP00000227163 | retinoic acid receptor, alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcrip [...] | spleen focus forming virus (SFFV) proviral integration oncogene spi1; Binds to the PU-box, a purine-rich DNA sequence (5’- GAGGAA-3’) that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity) | 0.907 |
SPI1 | RARA | ENSP00000227163 | ENSP00000254066 | spleen focus forming virus (SFFV) proviral integration oncogene spi1; Binds to the PU-box, a purine-rich DNA sequence (5’- GAGGAA-3’) that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity) | retinoic acid receptor, alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcrip [...] | 0.907 |
TNFRSF18 | IL2 | ENSP00000328207 | ENSP00000226730 | tumor necrosis factor receptor superfamily, member 18; Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.925 |