| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CLEC7A | PTTG1IP | ENSP00000302569 | ENSP00000328325 | C-type lectin domain family 7, member A | pituitary tumor-transforming 1 interacting protein; May facilitate PTTG1 nuclear translocation | 0.549 |
| LDLRAD1 | PTTG1IP | ENSP00000360411 | ENSP00000328325 | low density lipoprotein receptor class A domain containing 1 | pituitary tumor-transforming 1 interacting protein; May facilitate PTTG1 nuclear translocation | 0.537 |
| PTTG1 | PTTG1IP | ENSP00000344936 | ENSP00000328325 | pituitary tumor-transforming 1; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the tra [...] | pituitary tumor-transforming 1 interacting protein; May facilitate PTTG1 nuclear translocation | 0.942 |
| PTTG1 | TP53 | ENSP00000344936 | ENSP00000269305 | pituitary tumor-transforming 1; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the tra [...] | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.974 |
| PTTG1 | UBC | ENSP00000344936 | ENSP00000344818 | pituitary tumor-transforming 1; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the tra [...] | ubiquitin C | 0.999 |
| PTTG1IP | CLEC7A | ENSP00000328325 | ENSP00000302569 | pituitary tumor-transforming 1 interacting protein; May facilitate PTTG1 nuclear translocation | C-type lectin domain family 7, member A | 0.549 |
| PTTG1IP | LDLRAD1 | ENSP00000328325 | ENSP00000360411 | pituitary tumor-transforming 1 interacting protein; May facilitate PTTG1 nuclear translocation | low density lipoprotein receptor class A domain containing 1 | 0.537 |
| PTTG1IP | PTTG1 | ENSP00000328325 | ENSP00000344936 | pituitary tumor-transforming 1 interacting protein; May facilitate PTTG1 nuclear translocation | pituitary tumor-transforming 1; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the tra [...] | 0.942 |
| PTTG1IP | TP53 | ENSP00000328325 | ENSP00000269305 | pituitary tumor-transforming 1 interacting protein; May facilitate PTTG1 nuclear translocation | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.576 |
| PTTG1IP | UBC | ENSP00000328325 | ENSP00000344818 | pituitary tumor-transforming 1 interacting protein; May facilitate PTTG1 nuclear translocation | ubiquitin C | 0.943 |
| TP53 | PTTG1 | ENSP00000269305 | ENSP00000344936 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | pituitary tumor-transforming 1; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the tra [...] | 0.974 |
| TP53 | PTTG1IP | ENSP00000269305 | ENSP00000328325 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | pituitary tumor-transforming 1 interacting protein; May facilitate PTTG1 nuclear translocation | 0.576 |
| TP53 | UBC | ENSP00000269305 | ENSP00000344818 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | ubiquitin C | 0.999 |
| UBC | PTTG1 | ENSP00000344818 | ENSP00000344936 | ubiquitin C | pituitary tumor-transforming 1; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the tra [...] | 0.999 |
| UBC | PTTG1IP | ENSP00000344818 | ENSP00000328325 | ubiquitin C | pituitary tumor-transforming 1 interacting protein; May facilitate PTTG1 nuclear translocation | 0.943 |
| UBC | TP53 | ENSP00000344818 | ENSP00000269305 | ubiquitin C | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.999 |
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