26 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD4	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts (458 aa)
	DEFB129	defensin, beta 129; Has antibacterial activity (Potential) (183 aa)
	DEFB118	defensin, beta 118; Has antibacterial activity (Potential) (123 aa)
	DEFA4	defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production (97 aa)
	DEFA6	defensin, alpha 6, Paneth cell-specific; Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1 (100 aa)
	DEFB114	defensin, beta 114; Has antibacterial activity (By similarity) (69 aa)
	DEFB112	defensin, beta 112; Has antibacterial activity (By similarity) (113 aa)
	DEFB124	defensin, beta 124; Has antibacterial activity (Potential) (71 aa)
	DEFA3	defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane (94 aa)
	DEFA5	defensin, alpha 5, Paneth cell-specific; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (94 aa)
	DEFB128	defensin, beta 128; Has antibacterial activity (Potential) (93 aa)
	DEFB131	defensin, beta 131; Has antibacterial activity (Potential) (70 aa)
	DEFB110	defensin, beta 110 locus; Has antibacterial activity (By similarity) (67 aa)
	DEFB123	defensin, beta 123; Has antibacterial activity (Potential) (67 aa)
	DEFB135	defensin, beta 135; Has antibacterial activity (Potential) (77 aa)
	DEFB136	defensin, beta 136; Has antibacterial activity (Potential) (78 aa)
	DEFB132	defensin, beta 132; Has antibacterial activity (Potential) (95 aa)
	DEFB127	defensin, beta 127; Has antibacterial activity (Potential) (99 aa)
	DEFB126	defensin, beta 126; Has antibacterial activity (Potential) (111 aa)
	DEFB125	defensin, beta 125; Has antibacterial activity (Potential) (156 aa)
	DEFB113	defensin, beta 113; Has antibacterial activity (By similarity) (82 aa)
	DEFB133	defensin, beta 133; Has antibacterial activity (Potential) (61 aa)
	DEFB116	defensin, beta 116; Has antibacterial activity (By similarity) (102 aa)
	DEFB115	defensin, beta 115; Has antibacterial activity (By similarity) (88 aa)
	DEFB121	defensin, beta 121; Has antibacterial activity (Potential) (76 aa)
	DEFB134	defensin, beta 134; Has antibacterial activity (Potential) (66 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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TSV: tab separated values - can be opened in Excel

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DEFA3	DEFA4	ENSP00000328359	ENSP00000297435	defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane	defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production	0.907
DEFA3	DEFA5	ENSP00000328359	ENSP00000329890	defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane	defensin, alpha 5, Paneth cell-specific; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing	0.905
DEFA3	DEFA6	ENSP00000328359	ENSP00000297436	defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane	defensin, alpha 6, Paneth cell-specific; Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1	0.907
DEFA4	DEFA3	ENSP00000297435	ENSP00000328359	defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production	defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane	0.907
DEFA4	DEFA5	ENSP00000297435	ENSP00000329890	defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production	defensin, alpha 5, Paneth cell-specific; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing	0.905
DEFA4	DEFA6	ENSP00000297435	ENSP00000297436	defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production	defensin, alpha 6, Paneth cell-specific; Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1	0.907
DEFA5	DEFA3	ENSP00000329890	ENSP00000328359	defensin, alpha 5, Paneth cell-specific; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing	defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane	0.905
DEFA5	DEFA4	ENSP00000329890	ENSP00000297435	defensin, alpha 5, Paneth cell-specific; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing	defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production	0.905
DEFA5	DEFA6	ENSP00000329890	ENSP00000297436	defensin, alpha 5, Paneth cell-specific; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing	defensin, alpha 6, Paneth cell-specific; Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1	0.907
DEFA6	DEFA3	ENSP00000297436	ENSP00000328359	defensin, alpha 6, Paneth cell-specific; Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1	defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane	0.907
DEFA6	DEFA4	ENSP00000297436	ENSP00000297435	defensin, alpha 6, Paneth cell-specific; Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1	defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production	0.907
DEFA6	DEFA5	ENSP00000297436	ENSP00000329890	defensin, alpha 6, Paneth cell-specific; Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1	defensin, alpha 5, Paneth cell-specific; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing	0.907
DEFA6	DEFB123	ENSP00000297436	ENSP00000365486	defensin, alpha 6, Paneth cell-specific; Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1	defensin, beta 123; Has antibacterial activity (Potential)	0.422
DEFB110	DEFB123	ENSP00000360190	ENSP00000365486	defensin, beta 110 locus; Has antibacterial activity (By similarity)	defensin, beta 123; Has antibacterial activity (Potential)	0.434
DEFB110	DEFB126	ENSP00000360190	ENSP00000371835	defensin, beta 110 locus; Has antibacterial activity (By similarity)	defensin, beta 126; Has antibacterial activity (Potential)	0.590
DEFB110	DEFB131	ENSP00000360190	ENSP00000335538	defensin, beta 110 locus; Has antibacterial activity (By similarity)	defensin, beta 131; Has antibacterial activity (Potential)	0.943
DEFB112	DEFB126	ENSP00000319126	ENSP00000371835	defensin, beta 112; Has antibacterial activity (By similarity)	defensin, beta 126; Has antibacterial activity (Potential)	0.407
DEFB114	DEFB126	ENSP00000312702	ENSP00000371835	defensin, beta 114; Has antibacterial activity (By similarity)	defensin, beta 126; Has antibacterial activity (Potential)	0.509
DEFB118	DEFB121	ENSP00000253381	ENSP00000417128	defensin, beta 118; Has antibacterial activity (Potential)	defensin, beta 121; Has antibacterial activity (Potential)	0.703
DEFB118	DEFB123	ENSP00000253381	ENSP00000365486	defensin, beta 118; Has antibacterial activity (Potential)	defensin, beta 123; Has antibacterial activity (Potential)	0.645

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