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SAAL1 SAAL1 MUC1 MUC1 MUCL1 MUCL1 SELENBP1 SELENBP1 MUC21 MUC21 MUC15 MUC15 MUC3A MUC3A PKP3 PKP3 MUC2 MUC2 MUC17 MUC17 MUC19 MUC19 DSG4 DSG4 MUC12 MUC12 MUC16 MUC16 ST6GALNAC3 ST6GALNAC3 ST3GAL2 ST3GAL2 MUC7 MUC7 ST3GAL1 ST3GAL1 MUC5AC MUC5AC MUC5B MUC5B MUC4 MUC4 MUC20 MUC20 ST8SIA5 ST8SIA5 MUC13 MUC13 MUC6 MUC6 CAMK1 CAMK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CAMK1calcium/calmodulin-dependent protein kinase I; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippoc [...] (370 aa)
MUC7mucin 7, secreted; May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili (377 aa)
MUC17mucin 17, cell surface associated; Probably plays a role in maintaining homeostasis on mucosal surfaces (4493 aa)
MUCL1mucin-like 1; May play a role as marker for the diagnosis of metastatic breast cancer (90 aa)
MUC13mucin 13, cell surface associated; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling (511 aa)
ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1; It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O- linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values (340 aa)
ST8SIA5ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5; May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively (376 aa)
MUC3Amucin 3A, cell surface associated; Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity) (876 aa)
ST6GALNAC3ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity) (305 aa)
PKP3plakophilin 3; May play a role in junctional plaques (797 aa)
ST3GAL2ST3 beta-galactoside alpha-2,3-sialyltransferase 2; It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values (350 aa)
DSG4desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity) (1059 aa)
MUC1mucin 1, cell surface associated (475 aa)
SELENBP1selenium binding protein 1; Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity) (472 aa)
MUC21mucin 21, cell surface associated (566 aa)
MUC16mucin 16, cell surface associated; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity) (14507 aa)
MUC19mucin 19, oligomeric; May function in ocular mucus homeostasis (1640 aa)
MUC20mucin 20, cell surface associated; May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression (723 aa)
MUC6mucin 6, oligomeric mucus/gel-forming; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis (2439 aa)
MUC2mucin 2, oligomeric mucus/gel-forming; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer (2817 aa)
MUC15mucin 15, cell surface associated; May play a role in the cell adhesion to the extracellular matrix (361 aa)
MUC4mucin 4, cell surface associated (5412 aa)
SAAL1serum amyloid A-like 1 (474 aa)
MUC5ACmucin 5AC, oligomeric mucus/gel-forming (623 aa)
MUC5Bmucin 5B, oligomeric mucus/gel-forming (5762 aa)
MUC12mucin 12, cell surface associated; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium (5335 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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