node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP3S1 | KRT7 | ENSP00000325369 | ENSP00000329243 | adaptor-related protein complex 3, sigma 1 subunit; Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals | keratin 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7) | 0.404 |
AP3S1 | UBC | ENSP00000325369 | ENSP00000344818 | adaptor-related protein complex 3, sigma 1 subunit; Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals | ubiquitin C | 0.903 |
COG3 | COG7 | ENSP00000258654 | ENSP00000305442 | component of oligomeric golgi complex 3; Involved in ER-Golgi transport | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) | 0.999 |
COG3 | KRT7 | ENSP00000258654 | ENSP00000329243 | component of oligomeric golgi complex 3; Involved in ER-Golgi transport | keratin 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7) | 0.538 |
COG7 | COG3 | ENSP00000305442 | ENSP00000258654 | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) | component of oligomeric golgi complex 3; Involved in ER-Golgi transport | 0.999 |
COG7 | KRT7 | ENSP00000305442 | ENSP00000329243 | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) | keratin 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7) | 0.538 |
COG7 | UBC | ENSP00000305442 | ENSP00000344818 | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) | ubiquitin C | 0.483 |
DIDO1 | KRT7 | ENSP00000266070 | ENSP00000329243 | death inducer-obliterator 1 | keratin 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7) | 0.644 |
DIDO1 | UBC | ENSP00000266070 | ENSP00000344818 | death inducer-obliterator 1 | ubiquitin C | 0.622 |
EGFR | EIF3A | ENSP00000275493 | ENSP00000358140 | epidermal growth factor receptor | eukaryotic translation initiation factor 3, subunit A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | 0.570 |
EGFR | GRB2 | ENSP00000275493 | ENSP00000339007 | epidermal growth factor receptor | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.999 |
EGFR | KRT17 | ENSP00000275493 | ENSP00000308452 | epidermal growth factor receptor | keratin 17 | 0.562 |
EGFR | KRT7 | ENSP00000275493 | ENSP00000329243 | epidermal growth factor receptor | keratin 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7) | 0.559 |
EGFR | UBC | ENSP00000275493 | ENSP00000344818 | epidermal growth factor receptor | ubiquitin C | 0.999 |
EIF3A | EGFR | ENSP00000358140 | ENSP00000275493 | eukaryotic translation initiation factor 3, subunit A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | epidermal growth factor receptor | 0.570 |
EIF3A | KRT7 | ENSP00000358140 | ENSP00000329243 | eukaryotic translation initiation factor 3, subunit A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | keratin 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7) | 0.581 |
EIF3A | UBC | ENSP00000358140 | ENSP00000344818 | eukaryotic translation initiation factor 3, subunit A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | ubiquitin C | 0.998 |
ERLIN2 | KRT7 | ENSP00000276461 | ENSP00000329243 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | keratin 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7) | 0.644 |
ERLIN2 | UBC | ENSP00000276461 | ENSP00000344818 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | ubiquitin C | 0.919 |
GRB2 | EGFR | ENSP00000339007 | ENSP00000275493 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | epidermal growth factor receptor | 0.999 |