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ZDHHC14 ZDHHC14 ZDHHC9 ZDHHC9 ZDHHC18 ZDHHC18 GSPT1 GSPT1 ZDHHC19 ZDHHC19 ZDHHC12 ZDHHC12 GSPT2 GSPT2 ETF1 ETF1 ZDHHC5 ZDHHC5 UBB UBB ZDHHC22 ZDHHC22 UBC UBC ZDHHC8 ZDHHC8 ZDHHC23 ZDHHC23 LNX1 LNX1 ZDHHC11 ZDHHC11 ZDHHC24 ZDHHC24 AR AR ZDHHC21 ZDHHC21 ZDHHC3 ZDHHC3 TRMT112 TRMT112 TRMT12 TRMT12 ZDHHC1 ZDHHC1 ZDHHC7 ZDHHC7 ENSG00000268412 ENSG00000268412 ZDHHC11B ZDHHC11B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
LNX1ligand of numb-protein X 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity) (728 aa)
ZDHHC11zinc finger, DHHC-type containing 11 (412 aa)
ZDHHC5zinc finger, DHHC-type containing 5; Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity) (715 aa)
ZDHHC3zinc finger, DHHC-type containing 3; Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (By similarity) (327 aa)
ZDHHC19zinc finger, DHHC-type containing 19 (309 aa)
UBBubiquitin B (229 aa)
ZDHHC24zinc finger, DHHC-type containing 24 (284 aa)
ZDHHC22zinc finger, DHHC-type containing 22 (263 aa)
TRMT12tRNA methyltransferase 12 homolog (S. cerevisiae); Probable S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity) (448 aa)
ZDHHC23zinc finger, DHHC-type containing 23; May be involved in NOS1 regulation and targeting to the synaptic membrane (By similarity) (409 aa)
ZDHHC1zinc finger, DHHC-type containing 1 (485 aa)
GSPT2G1 to S phase transition 2; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (628 aa)
ZDHHC7zinc finger, DHHC-type containing 7; Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear re [...] (345 aa)
UBCubiquitin C (685 aa)
ZDHHC9zinc finger, DHHC-type containing 9 (364 aa)
ZDHHC14zinc finger, DHHC-type containing 14 (488 aa)
ETF1eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (437 aa)
ZDHHC12zinc finger, DHHC-type containing 12 (267 aa)
ZDHHC18zinc finger, DHHC-type containing 18; Has palmitoyltransferase activity towards HRAS and LCK (By similarity) (388 aa)
ARandrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (920 aa)
ZDHHC21zinc finger, DHHC-type containing 21; Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity) (265 aa)
ZDHHC8zinc finger, DHHC-type containing 8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1 (778 aa)
GSPT1G1 to S phase transition 1; Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (637 aa)
TRMT112tRNA methyltransferase 11-2 homolog (S. cerevisiae); Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5- methylation of ETF1 on ’Gln-185’, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (125 aa)
ZDHHC11Bzinc finger, DHHC-type containing 11B (382 aa)
ENSG00000268412Uncharacterized protein (135 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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