node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP13A2 | MEX3B | ENSP00000327214 | ENSP00000329918 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | mex-3 homolog B (C. elegans); RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms | 0.493 |
ATP13A2 | UBC | ENSP00000327214 | ENSP00000344818 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | ubiquitin C | 0.890 |
EIF2C1 | MEX3B | ENSP00000362300 | ENSP00000329918 | eukaryotic translation initiation factor 2C, 1; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs) | mex-3 homolog B (C. elegans); RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms | 0.968 |
EIF2C1 | PABPC1 | ENSP00000362300 | ENSP00000313007 | eukaryotic translation initiation factor 2C, 1; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs) | poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre- mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability [...] | 0.952 |
EIF2C1 | UBC | ENSP00000362300 | ENSP00000344818 | eukaryotic translation initiation factor 2C, 1; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs) | ubiquitin C | 0.811 |
MEX3B | ATP13A2 | ENSP00000329918 | ENSP00000327214 | mex-3 homolog B (C. elegans); RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | 0.493 |
MEX3B | EIF2C1 | ENSP00000329918 | ENSP00000362300 | mex-3 homolog B (C. elegans); RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms | eukaryotic translation initiation factor 2C, 1; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs) | 0.968 |
MEX3B | PABPC1 | ENSP00000329918 | ENSP00000313007 | mex-3 homolog B (C. elegans); RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms | poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre- mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability [...] | 0.572 |
MEX3B | SNUPN | ENSP00000329918 | ENSP00000309831 | mex-3 homolog B (C. elegans); RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms | snurportin 1; Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs | 0.743 |
MEX3B | UBC | ENSP00000329918 | ENSP00000344818 | mex-3 homolog B (C. elegans); RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms | ubiquitin C | 0.828 |
MEX3B | YWHAB | ENSP00000329918 | ENSP00000300161 | mex-3 homolog B (C. elegans); RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in bloc [...] | 0.572 |
MEX3B | YWHAE | ENSP00000329918 | ENSP00000264335 | mex-3 homolog B (C. elegans); RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.572 |
MEX3B | YWHAG | ENSP00000329918 | ENSP00000306330 | mex-3 homolog B (C. elegans); RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner | 0.572 |
MEX3B | YWHAH | ENSP00000329918 | ENSP00000248975 | mex-3 homolog B (C. elegans); RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 | 0.594 |
MEX3B | YWHAZ | ENSP00000329918 | ENSP00000309503 | mex-3 homolog B (C. elegans); RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.588 |
PABPC1 | EIF2C1 | ENSP00000313007 | ENSP00000362300 | poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre- mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability [...] | eukaryotic translation initiation factor 2C, 1; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs) | 0.952 |
PABPC1 | MEX3B | ENSP00000313007 | ENSP00000329918 | poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre- mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability [...] | mex-3 homolog B (C. elegans); RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms | 0.572 |
PABPC1 | UBC | ENSP00000313007 | ENSP00000344818 | poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre- mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability [...] | ubiquitin C | 0.998 |
RAP1GAP | UBC | ENSP00000290101 | ENSP00000344818 | RAP1 GTPase activating protein; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state | ubiquitin C | 0.807 |
RAP1GAP | YWHAB | ENSP00000290101 | ENSP00000300161 | RAP1 GTPase activating protein; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in bloc [...] | 0.922 |