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STRINGSTRING
CCDC155 CCDC155 PCYT1B PCYT1B SLC25A32 SLC25A32 PCYT1A PCYT1A RBM23 RBM23 SRPK1 SRPK1 PCYT2 PCYT2 RBM39 RBM39 SRPK2 SRPK2 PDSS2 PDSS2 PDSS1 PDSS1 RSRC2 RSRC2 RINT1 RINT1 CACTIN CACTIN UBQLN4 UBQLN4 UPF2 UPF2 CMTM5 CMTM5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CACTINcactin, spliceosome C complex subunit; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing (758 aa)
RBM39RNA binding motif protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process (530 aa)
RINT1RAD50 interactor 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. May play a role in cell cycle checkpoint control. Essential for telomere length control (792 aa)
PCYT1Aphosphate cytidylyltransferase 1, choline, alpha; Controls phosphatidylcholine synthesis (367 aa)
SLC25A32solute carrier family 25 (mitochondrial folate carrier) , member 32; Transports folate across the inner membranes of mitochondria (315 aa)
RSRC2arginine/serine-rich coiled-coil 2 (434 aa)
UPF2UPF2 regulator of nonsense transcripts homolog (yeast) (1272 aa)
CMTM5CKLF-like MARVEL transmembrane domain containing 5 (156 aa)
RBM23RNA binding motif protein 23; Probable RNA-binding protein. May be involved in pre- mRNA splicing process (439 aa)
UBQLN4ubiquilin 4; Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation (601 aa)
PDSS2prenyl (decaprenyl) diphosphate synthase, subunit 2; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10 (399 aa)
SRPK1SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] (655 aa)
PDSS1prenyl (decaprenyl) diphosphate synthase, subunit 1; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10 (415 aa)
PCYT1Bphosphate cytidylyltransferase 1, choline, beta; Controls phosphatidylcholine synthesis (369 aa)
SRPK2SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] (699 aa)
CCDC155coiled-coil domain containing 155; May be involved in meiotic chromosome dynamics and homolog pairing (By similarity) (562 aa)
PCYT2phosphate cytidylyltransferase 2, ethanolamine; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine (407 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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