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STRINGSTRING
NOC3L NOC3L OAT OAT DDX54 DDX54 GTPBP4 GTPBP4 RPL10L RPL10L ENO4 ENO4 RPL11 RPL11 RPL10 RPL10 RPL27 RPL27 ENO3 ENO3 DDX59 DDX59 RPL4 RPL4 ENO1 ENO1 DHX8 DHX8 CASC3 CASC3 ZCCHC17 ZCCHC17 MIB1 MIB1 MIB2 MIB2 ENO2 ENO2 MAGOH MAGOH PNPT1 PNPT1 POLDIP3 POLDIP3 ALYREF ALYREF PPIE PPIE MAGOHB MAGOHB RBM8A RBM8A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ENO2enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) (434 aa)
ENO1enolase 1, (alpha) (434 aa)
POLDIP3polymerase (DNA-directed), delta interacting protein 3 (421 aa)
RPL27ribosomal protein L27 (136 aa)
MIB1mindbomb E3 ubiquitin protein ligase 1 (1006 aa)
DHX8DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (1220 aa)
CASC3cancer susceptibility candidate 3; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influence [...] (703 aa)
RPL10Lribosomal protein L10-like; May play a role in compensating for the inactivated X- linked gene during spermatogenesis (214 aa)
RPL4ribosomal protein L4 (427 aa)
MAGOHBmago-nashi homolog B (Drosophila); Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway (By similarity) (148 aa)
DDX54DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors (882 aa)
ENO3enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration (434 aa)
DDX59DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 (619 aa)
RBM8ARNA binding motif protein 8A (174 aa)
RPL10ribosomal protein L10 (214 aa)
ZCCHC17zinc finger, CCHC domain containing 17 (241 aa)
ENO4enolase family member 4 (628 aa)
GTPBP4GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) (634 aa)
OATornithine aminotransferase (439 aa)
NOC3Lnucleolar complex associated 3 homolog (S. cerevisiae); May be required for adipogenesis (By similarity) (800 aa)
MAGOHmago-nashi homolog, proliferation-associated (Drosophila); Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mR [...] (146 aa)
PPIEpeptidylprolyl isomerase E (cyclophilin E); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) (314 aa)
RPL11ribosomal protein L11; Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity) (178 aa)
PNPT1polyribonucleotide nucleotidyltransferase 1; RNA-binding protein implicated in numerous RNA metabolic processes. Hydrolyzes single-stranded polyribonucleotides processively in the 3’-to-5’ direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3’ overhang double-stranded RNA with a 3’-to-5’ directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the trans [...] (783 aa)
ALYREFAly/REF export factor; Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO [...] (264 aa)
MIB2mindbomb E3 ubiquitin protein ligase 2 (1070 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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