node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENKUR | PIK3R1 | ENSP00000331044 | ENSP00000274335 | enkurin, TRPC channel interacting protein; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity) | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.633 |
ENKUR | TRPC1 | ENSP00000331044 | ENSP00000273482 | enkurin, TRPC channel interacting protein; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity) | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | 0.757 |
ENKUR | TRPC5 | ENSP00000331044 | ENSP00000262839 | enkurin, TRPC channel interacting protein; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity) | transient receptor potential cation channel, subfamily C, member 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion | 0.770 |
ENKUR | UBC | ENSP00000331044 | ENSP00000344818 | enkurin, TRPC channel interacting protein; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity) | ubiquitin C | 0.483 |
ENSG00000254469 | TRPC1 | ENSP00000434508 | ENSP00000273482 | Putative short transient receptor potential channel 2-like protein | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | 0.738 |
ENSG00000254469 | TRPC3 | ENSP00000434508 | ENSP00000368966 | Putative short transient receptor potential channel 2-like protein | transient receptor potential cation channel, subfamily C, member 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion | 0.755 |
ENSG00000254469 | TRPC4 | ENSP00000434508 | ENSP00000369003 | Putative short transient receptor potential channel 2-like protein | transient receptor potential cation channel, subfamily C, member 4 | 0.734 |
ENSG00000254469 | TRPC5 | ENSP00000434508 | ENSP00000262839 | Putative short transient receptor potential channel 2-like protein | transient receptor potential cation channel, subfamily C, member 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion | 0.734 |
ENSG00000254469 | TRPC6 | ENSP00000434508 | ENSP00000340913 | Putative short transient receptor potential channel 2-like protein | transient receptor potential cation channel, subfamily C, member 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion | 0.806 |
PIK3R1 | ENKUR | ENSP00000274335 | ENSP00000331044 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | enkurin, TRPC channel interacting protein; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity) | 0.633 |
PIK3R1 | UBC | ENSP00000274335 | ENSP00000344818 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | ubiquitin C | 0.938 |
TRPC1 | ENKUR | ENSP00000273482 | ENSP00000331044 | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | enkurin, TRPC channel interacting protein; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity) | 0.757 |
TRPC1 | ENSG00000254469 | ENSP00000273482 | ENSP00000434508 | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | Putative short transient receptor potential channel 2-like protein | 0.738 |
TRPC1 | TRPC3 | ENSP00000273482 | ENSP00000368966 | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | transient receptor potential cation channel, subfamily C, member 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion | 0.992 |
TRPC1 | TRPC4 | ENSP00000273482 | ENSP00000369003 | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | transient receptor potential cation channel, subfamily C, member 4 | 0.981 |
TRPC1 | TRPC5 | ENSP00000273482 | ENSP00000262839 | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | transient receptor potential cation channel, subfamily C, member 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion | 0.991 |
TRPC1 | TRPC6 | ENSP00000273482 | ENSP00000340913 | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | transient receptor potential cation channel, subfamily C, member 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion | 0.961 |
TRPC3 | ENSG00000254469 | ENSP00000368966 | ENSP00000434508 | transient receptor potential cation channel, subfamily C, member 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion | Putative short transient receptor potential channel 2-like protein | 0.755 |
TRPC3 | TRPC1 | ENSP00000368966 | ENSP00000273482 | transient receptor potential cation channel, subfamily C, member 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | 0.992 |
TRPC3 | TRPC4 | ENSP00000368966 | ENSP00000369003 | transient receptor potential cation channel, subfamily C, member 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion | transient receptor potential cation channel, subfamily C, member 4 | 0.961 |