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STRINGSTRING
APCS APCS LHB LHB CGA CGA GPR25 GPR25 CALCA CALCA ADM ADM FSHB FSHB CRHR2 CRHR2 ADRB2 ADRB2 GHRH GHRH ADORA2B ADORA2B RLN2 RLN2 PTH2R PTH2R PTGIR PTGIR CRHR1 CRHR1 GPR32 GPR32 HTR7 HTR7 GPR15 GPR15 ADCY2 ADCY2 GPR27 GPR27 GPR150 GPR150 GNG7 GNG7 GNB5 GNB5 GNG3 GNG3 GNG5 GNG5 GNG4 GNG4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
LHBluteinizing hormone beta polypeptide; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids (141 aa)
GHRHgrowth hormone releasing hormone; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone (108 aa)
FSHBfollicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs (129 aa)
APCSamyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin (223 aa)
GNB5guanine nucleotide binding protein (G protein), beta 5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (395 aa)
GPR32G protein-coupled receptor 32; Orphan receptor (356 aa)
PTH2Rparathyroid hormone 2 receptor; This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity) (550 aa)
ADMadrenomedullin; AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels (185 aa)
GPR15G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection (360 aa)
PTGIRprostaglandin I2 (prostacyclin) receptor (IP); Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase (386 aa)
GNG3guanine nucleotide binding protein (G protein), gamma 3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (75 aa)
GPR25G protein-coupled receptor 25; Orphan receptor (361 aa)
GPR27G protein-coupled receptor 27; Orphan receptor. Possible candidate for amine-like G- protein coupled receptor (375 aa)
ADORA2Badenosine A2b receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (332 aa)
ADRB2adrenoceptor beta 2, surface (413 aa)
CALCAcalcitonin-related polypeptide alpha; Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones (141 aa)
HTR75-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (479 aa)
CRHR2corticotropin releasing hormone receptor 2; This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (438 aa)
ADCY2adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (1091 aa)
GNG4guanine nucleotide binding protein (G protein), gamma 4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity) (75 aa)
CGAglycoprotein hormones, alpha polypeptide (116 aa)
GNG5guanine nucleotide binding protein (G protein), gamma 5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (68 aa)
GPR150G protein-coupled receptor 150; Orphan receptor (434 aa)
RLN2relaxin 2; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix (185 aa)
GNG7guanine nucleotide binding protein (G protein), gamma 7; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striat [...] (68 aa)
CRHR1corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (444 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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