7 items (Homo sapiens) - STRING network view

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	PSME3	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also b [...] (267 aa)
	FBXW5	F-box and WD repeat domain containing 5 (566 aa)
	DVL3	dishevelled, dsh homolog 3 (Drosophila); May play a role in the signal transduction pathway mediated by multiple Wnt genes (716 aa)
	TNFAIP8L1	tumor necrosis factor, alpha-induced protein 8-like 1 (186 aa)
	UBC	ubiquitin C (685 aa)
	GRK5	G protein-coupled receptor kinase 5; Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein- coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates- Hsc70- in [...] (590 aa)
	PAICS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (432 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DVL3	PSME3	ENSP00000316054	ENSP00000293362	dishevelled, dsh homolog 3 (Drosophila); May play a role in the signal transduction pathway mediated by multiple Wnt genes	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also b [...]	0.900
DVL3	TNFAIP8L1	ENSP00000316054	ENSP00000331827	dishevelled, dsh homolog 3 (Drosophila); May play a role in the signal transduction pathway mediated by multiple Wnt genes	tumor necrosis factor, alpha-induced protein 8-like 1	0.447
DVL3	UBC	ENSP00000316054	ENSP00000344818	dishevelled, dsh homolog 3 (Drosophila); May play a role in the signal transduction pathway mediated by multiple Wnt genes	ubiquitin C	0.997
FBXW5	TNFAIP8L1	ENSP00000313034	ENSP00000331827	F-box and WD repeat domain containing 5	tumor necrosis factor, alpha-induced protein 8-like 1	0.812
FBXW5	UBC	ENSP00000313034	ENSP00000344818	F-box and WD repeat domain containing 5	ubiquitin C	0.923
PAICS	TNFAIP8L1	ENSP00000382595	ENSP00000331827	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	tumor necrosis factor, alpha-induced protein 8-like 1	0.670
PAICS	UBC	ENSP00000382595	ENSP00000344818	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	ubiquitin C	0.984
PSME3	DVL3	ENSP00000293362	ENSP00000316054	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also b [...]	dishevelled, dsh homolog 3 (Drosophila); May play a role in the signal transduction pathway mediated by multiple Wnt genes	0.900
PSME3	TNFAIP8L1	ENSP00000293362	ENSP00000331827	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also b [...]	tumor necrosis factor, alpha-induced protein 8-like 1	0.607
PSME3	UBC	ENSP00000293362	ENSP00000344818	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also b [...]	ubiquitin C	0.996
TNFAIP8L1	DVL3	ENSP00000331827	ENSP00000316054	tumor necrosis factor, alpha-induced protein 8-like 1	dishevelled, dsh homolog 3 (Drosophila); May play a role in the signal transduction pathway mediated by multiple Wnt genes	0.447
TNFAIP8L1	FBXW5	ENSP00000331827	ENSP00000313034	tumor necrosis factor, alpha-induced protein 8-like 1	F-box and WD repeat domain containing 5	0.812
TNFAIP8L1	PAICS	ENSP00000331827	ENSP00000382595	tumor necrosis factor, alpha-induced protein 8-like 1	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	0.670
TNFAIP8L1	PSME3	ENSP00000331827	ENSP00000293362	tumor necrosis factor, alpha-induced protein 8-like 1	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also b [...]	0.607
UBC	DVL3	ENSP00000344818	ENSP00000316054	ubiquitin C	dishevelled, dsh homolog 3 (Drosophila); May play a role in the signal transduction pathway mediated by multiple Wnt genes	0.997
UBC	FBXW5	ENSP00000344818	ENSP00000313034	ubiquitin C	F-box and WD repeat domain containing 5	0.923
UBC	PAICS	ENSP00000344818	ENSP00000382595	ubiquitin C	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	0.984
UBC	PSME3	ENSP00000344818	ENSP00000293362	ubiquitin C	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also b [...]	0.996

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