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STRINGSTRING
COL15A1 COL15A1 COL16A1 COL16A1 COL8A2 COL8A2 COL13A1 COL13A1 COL3A1 COL3A1 COL6A2 COL6A2 COL21A1 COL21A1 COL11A1 COL11A1 COL5A3 COL5A3 COL6A1 COL6A1 COL7A1 COL7A1 COL5A2 COL5A2 COL6A3 COL6A3 COL4A5 COL4A5 COL18A1 COL18A1 COL2A1 COL2A1 COL4A6 COL4A6 F12 F12 COL4A4 COL4A4 COL27A1 COL27A1 COL1A2 COL1A2 COL4A3 COL4A3 ITGA1 ITGA1 ITGB1 ITGB1 ALPL ALPL ITGB3 ITGB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
COL21A1collagen, type XXI, alpha 1 (957 aa)
F12coagulation factor XII (Hageman factor); Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (615 aa)
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. [...] (788 aa)
COL5A3collagen, type V, alpha 3; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (1745 aa)
ITGA1integrin, alpha 1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen (1179 aa)
COL6A3collagen, type VI, alpha 3; Collagen VI acts as a cell-binding protein (3177 aa)
COL1A2collagen, type I, alpha 2 (1366 aa)
COL6A2collagen, type VI, alpha 2 (1019 aa)
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (798 aa)
COL3A1collagen, type III, alpha 1 (1466 aa)
COL8A2collagen, type VIII, alpha 2; Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity) (703 aa)
COL4A5collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1691 aa)
COL7A1collagen, type VII, alpha 1; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen (2944 aa)
COL18A1collagen, type XVIII, alpha 1 (1519 aa)
COL27A1collagen, type XXVII, alpha 1; Plays a role during the calcification of cartilage and the transition of cartilage to bone (1860 aa)
COL6A1collagen, type VI, alpha 1; Collagen VI acts as a cell-binding protein (1028 aa)
COL11A1collagen, type XI, alpha 1 (1806 aa)
COL4A6collagen, type IV, alpha 6 (1691 aa)
COL16A1collagen, type XVI, alpha 1; Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology (1604 aa)
ALPLalkaline phosphatase, liver/bone/kidney (524 aa)
COL5A2collagen, type V, alpha 2 (1499 aa)
COL15A1collagen, type XV, alpha 1; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle (1388 aa)
COL2A1collagen, type II, alpha 1 (1487 aa)
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen) (1670 aa)
COL4A4collagen, type IV, alpha 4; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1690 aa)
COL13A1collagen, type XIII, alpha 1 (717 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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