Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
GABARAP GABARAP BEST2 BEST2 GABRB1 GABRB1 GABRB3 GABRB3 GABRB2 GABRB2 GABRA3 GABRA3 GABRA2 GABRA2 GABRG2 GABRG2 GABRA6 GABRA6 GABRP GABRP GABRA5 GABRA5 GABRA4 GABRA4 GABRA1 GABRA1 GABRE GABRE CFTR CFTR GABRG3 GABRG3 CLCN2 CLCN2 CLIC3 CLIC3 CLIC4 CLIC4 BEST1 BEST1 GLRA1 GLRA1 GABRR2 GABRR2 CLIC5 CLIC5 CLCN1 CLCN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
GABRA1gamma-aminobutyric acid (GABA) A receptor, alpha 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (456 aa)
BEST2bestrophin 2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate (509 aa)
CLIC5chloride intracellular channel 5; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Required for normal formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (410 aa)
GABRA4gamma-aminobutyric acid (GABA) A receptor, alpha 4; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (554 aa)
GABRPgamma-aminobutyric acid (GABA) A receptor, pi; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone (440 aa)
CLCN2chloride channel, voltage-sensitive 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport (898 aa)
GABRA6gamma-aminobutyric acid (GABA) A receptor, alpha 6; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (453 aa)
GABRB2gamma-aminobutyric acid (GABA) A receptor, beta 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (512 aa)
GABRB1gamma-aminobutyric acid (GABA) A receptor, beta 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (474 aa)
GABRB3gamma-aminobutyric acid (GABA) A receptor, beta 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (473 aa)
GABARAPGABA(A) receptor-associated protein; May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity) (117 aa)
GABRG3gamma-aminobutyric acid (GABA) A receptor, gamma 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (467 aa)
GABRA5gamma-aminobutyric acid (GABA) A receptor, alpha 5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (462 aa)
CLCN1chloride channel, voltage-sensitive 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport (988 aa)
GABRA2gamma-aminobutyric acid (GABA) A receptor, alpha 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (451 aa)
GABRA3gamma-aminobutyric acid (GABA) A receptor, alpha 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (492 aa)
GABREgamma-aminobutyric acid (GABA) A receptor, epsilon; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (506 aa)
CLIC4chloride intracellular channel 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis) (253 aa)
GABRR2gamma-aminobutyric acid (GABA) A receptor, rho 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission (490 aa)
BEST1bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate (604 aa)
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (515 aa)
GLRA1glycine receptor, alpha 1; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) (457 aa)
CLIC3chloride intracellular channel 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control (236 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (38%)