node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AURKA | SRPK1 | ENSP00000216911 | ENSP00000362931 | aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | 0.567 |
AURKA | UBC | ENSP00000216911 | ENSP00000344818 | aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] | ubiquitin C | 0.999 |
SRPK1 | AURKA | ENSP00000362931 | ENSP00000216911 | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] | 0.567 |
SRPK1 | TCEAL2 | ENSP00000362931 | ENSP00000332359 | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | 0.461 |
SRPK1 | UBC | ENSP00000362931 | ENSP00000344818 | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | ubiquitin C | 0.741 |
TCEAL1 | TCEAL2 | ENSP00000361707 | ENSP00000332359 | transcription elongation factor A (SII)-like 1; May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | 0.999 |
TCEAL1 | TCEAL4 | ENSP00000361707 | ENSP00000415564 | transcription elongation factor A (SII)-like 1; May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | 0.999 |
TCEAL1 | USP11 | ENSP00000361707 | ENSP00000218348 | transcription elongation factor A (SII)-like 1; May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly | ubiquitin specific peptidase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks | 0.943 |
TCEAL2 | SRPK1 | ENSP00000332359 | ENSP00000362931 | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | 0.461 |
TCEAL2 | TCEAL1 | ENSP00000332359 | ENSP00000361707 | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | transcription elongation factor A (SII)-like 1; May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly | 0.999 |
TCEAL2 | TCEAL4 | ENSP00000332359 | ENSP00000415564 | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | 0.999 |
TCEAL2 | UBC | ENSP00000332359 | ENSP00000344818 | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | ubiquitin C | 0.721 |
TCEAL2 | USP11 | ENSP00000332359 | ENSP00000218348 | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | ubiquitin specific peptidase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks | 0.891 |
TCEAL4 | TCEAL1 | ENSP00000415564 | ENSP00000361707 | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | transcription elongation factor A (SII)-like 1; May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly | 0.999 |
TCEAL4 | TCEAL2 | ENSP00000415564 | ENSP00000332359 | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | 0.999 |
TCEAL4 | UBC | ENSP00000415564 | ENSP00000344818 | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | ubiquitin C | 0.954 |
TCEAL4 | USP11 | ENSP00000415564 | ENSP00000218348 | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | ubiquitin specific peptidase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks | 0.891 |
UBC | AURKA | ENSP00000344818 | ENSP00000216911 | ubiquitin C | aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] | 0.999 |
UBC | SRPK1 | ENSP00000344818 | ENSP00000362931 | ubiquitin C | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | 0.741 |
UBC | TCEAL2 | ENSP00000344818 | ENSP00000332359 | ubiquitin C | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | 0.721 |