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SCFD1 SCFD1 P4HA3 P4HA3 SEC22A SEC22A TRAPPC6A TRAPPC6A SAR1B SAR1B SEC31A SEC31A RAB1A RAB1A PREB PREB CNIH CNIH GOLGA2 GOLGA2 TFG TFG COL27A1 COL27A1 COL4A6 COL4A6 LMAN1 LMAN1 COL5A1 COL5A1 COL20A1 COL20A1 PPIB PPIB COL15A1 COL15A1 COL1A2 COL1A2 MCFD2 MCFD2 COL8A1 COL8A1 CRTAP CRTAP COL13A1 COL13A1 COL12A1 COL12A1 COL7A1 COL7A1 LMAN2L LMAN2L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
TRAPPC6Atrafficking protein particle complex 6A; May play a role in vesicular transport during the biogenesis of melanosomes (By similarity) (173 aa)
CNIHcornichon homolog (Drosophila); Involved in the selective transport and maturation of TGF-alpha family proteins (144 aa)
TFGTRK-fused gene (400 aa)
LMAN1lectin, mannose-binding, 1 (510 aa)
PREBprolactin regulatory element binding; Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER (417 aa)
COL8A1collagen, type VIII, alpha 1; Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (744 aa)
COL1A2collagen, type I, alpha 2 (1366 aa)
PPIBpeptidylprolyl isomerase B (cyclophilin B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (216 aa)
SEC22ASEC22 vesicle trafficking protein homolog A (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (By similarity) (307 aa)
MCFD2multiple coagulation factor deficiency 2; The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors (146 aa)
CRTAPcartilage associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues (401 aa)
COL12A1collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) (3063 aa)
P4HA3prolyl 4-hydroxylase, alpha polypeptide III; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins (544 aa)
COL7A1collagen, type VII, alpha 1; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen (2944 aa)
SEC31ASEC31 homolog A (S. cerevisiae) (1220 aa)
COL27A1collagen, type XXVII, alpha 1; Plays a role during the calcification of cartilage and the transition of cartilage to bone (1860 aa)
COL20A1collagen, type XX, alpha 1; Probable collagen protein (1284 aa)
COL5A1collagen, type V, alpha 1; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (1838 aa)
COL4A6collagen, type IV, alpha 6 (1691 aa)
COL15A1collagen, type XV, alpha 1; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle (1388 aa)
LMAN2Llectin, mannose-binding 2-like; May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53 (359 aa)
COL13A1collagen, type XIII, alpha 1 (717 aa)
SAR1BSAR1 homolog B (S. cerevisiae); Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (198 aa)
RAB1ARAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity (205 aa)
SCFD1sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity) (642 aa)
GOLGA2golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure (1002 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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