Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | YIPF2 | Yip1 domain family, member 2 (316 aa) | ||
 | RAB33A | RAB33A, member RAS oncogene family (237 aa) | ||
 | YPEL5 | yippee-like 5 (Drosophila) (121 aa) | ||
 | RAB11A | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] (216 aa) | ||
 | ABHD2 | abhydrolase domain containing 2; May play a role in smooth muscle cells migration (By similarity) (425 aa) | ||
 | ABHD3 | abhydrolase domain containing 3 (409 aa) | ||
 | YPEL4 | yippee-like 4 (Drosophila) (127 aa) | ||
 | RAB33B | RAB33B, member RAS oncogene family; Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation (229 aa) | ||
 | RAB1B | RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (201 aa) | ||
 | SEC13 | SEC13 homolog (S. cerevisiae); Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (322 aa) | ||
 | YPEL2 | yippee-like 2 (Drosophila) (119 aa) | ||
 | RAB43 | RAB43, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport o [...] (212 aa) | ||
 | ABHD1 | abhydrolase domain containing 1 (405 aa) | ||
 | YIPF7 | Yip1 domain family, member 7 (280 aa) | ||
 | RAB11B | RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) (218 aa) | ||
 | YPEL1 | yippee-like 1 (Drosophila); May play a role in epithelioid conversion of fibroblasts (119 aa) | ||
 | RAB19 | RAB19, member RAS oncogene family (217 aa) | ||
 | RAB25 | RAB25, member RAS oncogene family; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity) (213 aa) | ||
 | RABL6 | RAB, member RAS oncogene family-like 6 (730 aa) | ||
 | RABL2A | RAB, member of RAS oncogene family-like 2A (228 aa) | ||
 | RABL2B | RAB, member of RAS oncogene family-like 2B (238 aa) | ||
 | YPEL3 | yippee-like 3 (Drosophila); Involved in proliferation and apoptosis in myeloid precursor cells (By similarity) (157 aa) | ||
 | RAB1A | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity (205 aa) | ||
 | YIPF6 | Yip1 domain family, member 6 (236 aa) | ||
 | ENSG00000259024 | FAM18B2-CDRT4 readthrough (164 aa) | ||
 | USO1 | USO1 vesicle docking protein homolog (yeast); General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (By similarity) (971 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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