26 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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Your Input:
	MRPL32	mitochondrial ribosomal protein L32 (188 aa)
	MRPL27	mitochondrial ribosomal protein L27 (148 aa)
	TP53I3	tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) (332 aa)
	MRPL34	mitochondrial ribosomal protein L34 (92 aa)
	RPL35	ribosomal protein L35 (123 aa)
	MRPL15	mitochondrial ribosomal protein L15 (296 aa)
	MRPL3	mitochondrial ribosomal protein L3 (348 aa)
	MRPL17	mitochondrial ribosomal protein L17 (175 aa)
	MRPL10	mitochondrial ribosomal protein L10 (271 aa)
	MRPL33	mitochondrial ribosomal protein L33 (65 aa)
	ICT1	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (206 aa)
	MRPL11	mitochondrial ribosomal protein L11 (192 aa)
	MRPL1	mitochondrial ribosomal protein L1 (325 aa)
	MRPL12	mitochondrial ribosomal protein L12 (198 aa)
	MRPL20	mitochondrial ribosomal protein L20 (149 aa)
	RPL9	ribosomal protein L9 (192 aa)
	MRPL37	mitochondrial ribosomal protein L37 (423 aa)
	RPL12	ribosomal protein L12; Binds directly to 26S ribosomal RNA (By similarity) (165 aa)
	RPL5	ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA (297 aa)
	RPL11	ribosomal protein L11; Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity) (178 aa)
	MRPL36	mitochondrial ribosomal protein L36; Component of the large subunit of the mitochondrial ribosome (Potential) (103 aa)
	MRPL19	mitochondrial ribosomal protein L19 (292 aa)
	RPL23	ribosomal protein L23 (140 aa)
	RPL23A	ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity) (156 aa)
	RNASET2	ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism (256 aa)
	MRPL42	mitochondrial ribosomal protein L42 (142 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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MFA: multi-fasta format - containing the aminoacid sequences in the network

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ICT1	MRPL1	ENSP00000301585	ENSP00000315017	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L1	0.453
ICT1	MRPL10	ENSP00000301585	ENSP00000290208	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L10	0.928
ICT1	MRPL11	ENSP00000301585	ENSP00000308897	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L11	0.652
ICT1	MRPL12	ENSP00000301585	ENSP00000333837	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L12	0.987
ICT1	MRPL15	ENSP00000301585	ENSP00000260102	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L15	0.494
ICT1	MRPL17	ENSP00000301585	ENSP00000288937	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L17	0.582
ICT1	MRPL19	ENSP00000301585	ENSP00000377486	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L19	0.463
ICT1	MRPL20	ENSP00000301585	ENSP00000341082	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L20	0.580
ICT1	MRPL27	ENSP00000301585	ENSP00000225969	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L27	0.521
ICT1	MRPL3	ENSP00000301585	ENSP00000264995	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L3	0.986
ICT1	MRPL32	ENSP00000301585	ENSP00000223324	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L32	0.480
ICT1	MRPL42	ENSP00000301585	ENSP00000447547	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L42	0.903
ICT1	RPL12	ENSP00000301585	ENSP00000354739	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	ribosomal protein L12; Binds directly to 26S ribosomal RNA (By similarity)	0.521
ICT1	TP53I3	ENSP00000301585	ENSP00000238721	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro)	0.922
MRPL1	ICT1	ENSP00000315017	ENSP00000301585	mitochondrial ribosomal protein L1	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	0.453
MRPL1	MRPL10	ENSP00000315017	ENSP00000290208	mitochondrial ribosomal protein L1	mitochondrial ribosomal protein L10	0.909
MRPL1	MRPL11	ENSP00000315017	ENSP00000308897	mitochondrial ribosomal protein L1	mitochondrial ribosomal protein L11	0.999
MRPL1	MRPL12	ENSP00000315017	ENSP00000333837	mitochondrial ribosomal protein L1	mitochondrial ribosomal protein L12	0.989
MRPL1	MRPL15	ENSP00000315017	ENSP00000260102	mitochondrial ribosomal protein L1	mitochondrial ribosomal protein L15	0.968
MRPL1	MRPL17	ENSP00000315017	ENSP00000288937	mitochondrial ribosomal protein L1	mitochondrial ribosomal protein L17	0.971

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