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VANGL1 VANGL1 INTU INTU DVL1 DVL1 CELSR2 CELSR2 FRZB FRZB CELSR1 CELSR1 CELSR3 CELSR3 CXXC1 CXXC1 VANGL2 VANGL2 NSD1 NSD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CELSR3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation (3312 aa)
CELSR1cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation (3014 aa)
CELSR2cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation (2923 aa)
FRZBfrizzled-related protein; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (325 aa)
VANGL1vang-like 1 (van gogh, Drosophila) (524 aa)
INTUinturned planar cell polarity effector homolog (Drosophila); Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity) (942 aa)
VANGL2vang-like 2 (van gogh, Drosophila); Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process (By similarity) (521 aa)
DVL1dishevelled, dsh homolog 1 (Drosophila); Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (670 aa)
CXXC1CXXC finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG (660 aa)
NSD1nuclear receptor binding SET domain protein 1; Histone methyltransferase. Preferentially methylates ’Lys-36’ of histone H3 and ’Lys-20’ of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context (2696 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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